Extracorporeal irradiation of the blood. Histological examinations of homografts in patients undergoing immunosuppressive therapy with ECIB before kidney transplantation.

Acta pathologica et microbiologica Scandinavica. Section A, Pathology Pub Date : 2009-08-15 DOI:10.1111/J.1699-0463.1974.TB00364.X

E. Weeke, B. Henriksen

{"title":"Extracorporeal irradiation of the blood. Histological examinations of homografts in patients undergoing immunosuppressive therapy with ECIB before kidney transplantation.","authors":"E. Weeke, B. Henriksen","doi":"10.1111/J.1699-0463.1974.TB00364.X","DOIUrl":null,"url":null,"abstract":"By means of extracorporeal irradiation of the blood (ECIB) lymphopenia is produced in man. This method has been used in the clinical work as immunosuppressive therapy before and after renal transplantation. In the present study, the histological changes of acute and chronic rejection in non-surviving kidney grafts were compared in 29 patients who received ECIB before and after grafting (group I) and 42 non-ECIB treated patients (group II). The median survival time of the graft was 45 days (range 2–790). In addition, the histological changes in biopsies from the grafts taken during early acute rejection episodes were studied. The histological changes were divided in acute rejection and chronic changes and graded according to the severity of the observed changes. Furthermore, the degree of mononuclear cell infiltration were evaluated. No statistical difference between group I and II, neither regarding histological changes in the grafted kidneys nor in the biopsies, could be demonstrated.","PeriodicalId":6953,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","volume":"29 1","pages":"389-96"},"PeriodicalIF":0.0000,"publicationDate":"2009-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pathologica et microbiologica Scandinavica. Section A, Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/J.1699-0463.1974.TB00364.X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

By means of extracorporeal irradiation of the blood (ECIB) lymphopenia is produced in man. This method has been used in the clinical work as immunosuppressive therapy before and after renal transplantation. In the present study, the histological changes of acute and chronic rejection in non-surviving kidney grafts were compared in 29 patients who received ECIB before and after grafting (group I) and 42 non-ECIB treated patients (group II). The median survival time of the graft was 45 days (range 2–790). In addition, the histological changes in biopsies from the grafts taken during early acute rejection episodes were studied. The histological changes were divided in acute rejection and chronic changes and graded according to the severity of the observed changes. Furthermore, the degree of mononuclear cell infiltration were evaluated. No statistical difference between group I and II, neither regarding histological changes in the grafted kidneys nor in the biopsies, could be demonstrated.

查看原文本刊更多论文

血液的体外照射同种移植物在肾移植前接受ECIB免疫抑制治疗的组织学检查。

通过体外血液照射(ECIB)，在人体内产生淋巴细胞减少症。该方法已在临床工作中作为肾移植前后的免疫抑制疗法。本研究比较了29例接受ECIB治疗的患者(I组)和42例未接受ECIB治疗的患者(II组)在移植前后急性和慢性排斥反应的组织学变化。移植肾的中位生存时间为45天(范围2-790天)。此外，我们还研究了早期急性排斥反应期间移植物活检的组织学变化。组织学变化分为急性排斥反应和慢性排斥反应，并根据观察到的变化的严重程度进行分级。进一步评价单核细胞浸润程度。无论是移植肾的组织学改变还是活检结果，I组和II组之间都没有统计学差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta pathologica et microbiologica Scandinavica. Section A, Pathology

自引率

0.00%

发文量