The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

IF 0.5 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Revista Romana De Medicina De Laborator Pub Date : 2022-01-01 DOI:10.2478/rrlm-2021-0036

S. Avnioglu, M. Güngör, E. Kurutaş, Unal Ozturk, I. Demirhan, S. Bakarış, H. A. Velioglu, Seyda Cankaya, B. Yulug

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引用次数: 2

Abstract

Abstract Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.

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白藜芦醇对实验性心脏缺血再灌注模型鞘氨醇-1和氧化/亚硝化应激的影响

摘要目的:白藜芦醇(Resveratrol, RSV)是一种具有显著抗氧化作用的天然多酚类化合物。在这项研究中，我们旨在研究白藜芦醇对心脏缺血再灌注(I/R)中鞘氨醇-1-磷酸(S1P)和氧化应激生物标志物的影响。材料与方法:采用ELISA和光镜观察RSV对心肌缺血再灌注损伤的生化和组织病理学影响。结果:治疗组丙二醛(MDA)水平、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)活性与对照组比较，差异均有统计学意义(p<0.05)。组织病理学上，我们还观察到，与I/R组和假手术组相比，治疗组多形核白细胞(PMNL)浸润、心肌水肿、肌溶现象减少。结论:白藜芦醇可能通过其抗炎和抗氧化作用在心脏I/R损伤中发挥重要作用，本研究已得到生物化学和组织病理学证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Romana De Medicina De Laborator MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

0.31

自引率

20.00%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of the journal is to publish new information that would lead to a better understanding of biological mechanisms of production of human diseases, their prevention and diagnosis as early as possible and to monitor therapy and the development of the health of patients