Dependence of 18F Production Yield and Radioactive Impurities on Proton Irradiation Dose

Physics Research International Pub Date : 2017-10-09 DOI:10.1155/2017/2124383

I. Kambali, Parwanto, H. Suryanto, Nur Huda, Ferdi D. Listiawadi, Herta Astarina, Ratu R. Ismuha, Kardinah

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引用次数: 16

Abstract

Radiation safety for patients during positron emission tomography (PET) procedures is affected by the amount of radioactive impurities generated during production of fluorine-18 (18F) radionuclide. In this investigation, the dependence of 18F production yield and radioactive impurities on proton irradiation dose is discussed. Enriched water ( ) target was bombarded perpendicularly by 11-MeV proton beams at various proton doses. Experimental results indicated that the 18F radioactivity yield and the amount of 56Co and radioactive impurities depend strongly on the proton dose. In the proton dose range between 2 μAhr and 20 μAhr, the radioactive impurities increased with increasing proton dose. There was no significant difference in the radioactivity yield of both 56Co and impurities at low proton dose between 2 and 10 μAhr. However a huge difference was recorded when the dose was increased above 10 μAhr. The experimental data can be used to predict the amount of impurities generated during 18F production at proton dose of higher than 20 μAhr.

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质子辐照剂量对18F产率和放射性杂质的影响

正电子发射断层扫描(PET)过程中患者的辐射安全受到氟-18 (18F)放射性核素生产过程中产生的放射性杂质数量的影响。本文讨论了质子辐照剂量对18F产率和放射性杂质的影响。用不同质子剂量的11-MeV质子束垂直轰击富集水靶。实验结果表明，18F的放射性产率、56Co和放射性杂质的数量与质子剂量有很大关系。在质子剂量2 ~ 20 μAhr范围内，放射性杂质随质子剂量的增加而增加。低质子剂量下56Co和杂质的放射性产率在2和10 μAhr之间没有显著差异。然而，当剂量增加到10 μAhr以上时，出现了巨大的差异。实验数据可用于预测质子剂量大于20 μAhr时18F生成过程中杂质的数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Physics Research International

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