Modified Layered Double Hydroxide – PEG Magneto-Sensitive Hydrogels with Suitable Ligno-Alginate Green Polymer Composite for Prolonged Drug Delivery Applications

Abstract

: A new nanocarrier was developed to address the debilitating side effects associated with cancer treatment, specifically for delivering Sorafenib (SF). This nanocarrier utilises biodegradable polymers, which present a promising approach to anti-cancer therapy by enabling controlled drug release and reduced toxicity. The design of the nanocarrier includes Fe 3 O 4 nanoparticles, Sodium alginate, Lignosulphonic acid, Polyethylene glycol, SF drug, and a MgAl layered double hydroxide coating. The nanocarrier was extensively characterised using various techniques, including FT-IR, TGA, and FESEM. Notably, the IONP nanocarrier demonstrated remarkable superiority in the controlled release of SF compared to other variations. The chemical interactions among the components of the nanocarrier significantly contributed to its enhanced stability, as evidenced by thermogravimetric analysis. Furthermore, XRD analysis