Glanzmann’s Thrombasthenia in the Parturient Undergoing Cesarean Delivery- A Case Report and Discussion of Clinical Consideration

Abstract

Glanzmann thrombasthenia (GT) is a rare hemorrhagic disorder characterized by the absence of IIb-IIIa platelet glycoprotein (GPIIbIIIa) on the platelet surface. Many GT patients experience recurrent bleeding and require frequent platelet transfusion. Therefore, they are at risk for alloimmunization against platelet glycoprotein or Human leucocyte antigen (HLA) epitopes resulting in platelet refractoriness and therapeutic failure. We report a unique case of GT in pregnancy at risk for severe postpartum hemorrhage due to anti-GP IIb/IIIa and anti-HLA antibodies and the use of pro-hemostatic agents to optimize outcomes. A multidisciplinary approach is essential to achieving the best possible outcomes for these patients.