Effect of citalopram combined with psychological intervention on cellular immunity and negative emotion in patients with primary liver cancer

Abstract

To explore the effect of citalopram combined with psychological intervention on cellular immune function and negative emotion in patients with primary liver cancer. 124 patients with primary liver cancer from June 2018 to August 2019 were selected. 62 in the observation and 62 in the control. In the control received routine interventional therapy for liver cancer, while in the observation were treated with citalopram combined with psychological intervention. Before and after treatment, CD3+, CD4+, CD4+/CD8+, NK cells and other cellular immune indexes were compared; core quality of life scale scores of cancer patients before and after treatment were compared; MMSE, HAMD and HAMA scores. The levels of CD3+, CD4+, CD4+/CD8+ and NK cells in the observation were higher than in the control after treatment. After treatment, MMSE 83.17 ± 4.47, HAMD 67.51 ± 7.71 and HAMA 60.42 ± 5.83 in the observation group were higher than those in the control group. Citalopram combined with psychological intervention in the treatment of patients with primary liver cancer is conducive to the protection of cellular immune function, and has positive significance in regulating patients’ mood, improving patients’ psychology and improving patients’ quality of life.