STUDY THE BIOLOGICAL ACTIVITY OF Moringa oleifera AND COFFEE BEANS ON FUNCTIONS AND HISTOLOGY OF LIVER AND KIDNEY IN DIABETIC RATS

Egyptian Journal of Agricultural Sciences Pub Date : 2020-07-01 DOI:10.21608/ejarc.2020.210223

Aziza Salah El Din, Dalia Hassan

{"title":"STUDY THE BIOLOGICAL ACTIVITY OF Moringa oleifera AND COFFEE BEANS ON FUNCTIONS AND HISTOLOGY OF LIVER AND KIDNEY IN DIABETIC RATS","authors":"Aziza Salah El Din, Dalia Hassan","doi":"10.21608/ejarc.2020.210223","DOIUrl":null,"url":null,"abstract":"Diabetes mellitus (DM) is associated with hyperglycemia, abnormal lipid profiles and inflammatory disorders. The extracts from leaves of Moringa oleifera or beans of green coffee were found to treat metabolic disorders as good sources of polyphenols and flavonoids. Also, coffee is a rich source of dietary antioxidants and chlorogenic acid. The present study aimed to evaluate the protective effect of the ethanolic extract of Moringa oleifera (MO) and beans of green coffee (GC) in alloxan induced diabetic rats, the stress oxidant, hepatic-kidney dysfunction and histological changes in liver and kidneys of different experimental groups of rats. The extracts were administered using the gastric tube of rats. Results ascertained that orally administration with ethanolic extract of green coffee beans and Moringa leaves significantly reduced serum glucose level (P < 0.05), improved serum lipid profiles, liver function enzymes and kidney functions in diabetic rats after 28 days. Histological sections of the liver and kidney tissues showed the protective effects of MO and GC in the treated rats. It is noteworthy that there is a synergistic effect between Moringa leaves and green coffee beans.","PeriodicalId":11430,"journal":{"name":"Egyptian Journal of Agricultural Sciences","volume":"105 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Agricultural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ejarc.2020.210223","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Diabetes mellitus (DM) is associated with hyperglycemia, abnormal lipid profiles and inflammatory disorders. The extracts from leaves of Moringa oleifera or beans of green coffee were found to treat metabolic disorders as good sources of polyphenols and flavonoids. Also, coffee is a rich source of dietary antioxidants and chlorogenic acid. The present study aimed to evaluate the protective effect of the ethanolic extract of Moringa oleifera (MO) and beans of green coffee (GC) in alloxan induced diabetic rats, the stress oxidant, hepatic-kidney dysfunction and histological changes in liver and kidneys of different experimental groups of rats. The extracts were administered using the gastric tube of rats. Results ascertained that orally administration with ethanolic extract of green coffee beans and Moringa leaves significantly reduced serum glucose level (P < 0.05), improved serum lipid profiles, liver function enzymes and kidney functions in diabetic rats after 28 days. Histological sections of the liver and kidney tissues showed the protective effects of MO and GC in the treated rats. It is noteworthy that there is a synergistic effect between Moringa leaves and green coffee beans.

查看原文本刊更多论文

摘要研究辣木和咖啡豆对糖尿病大鼠肝肾功能和组织学的生物活性

糖尿病(DM)与高血糖、血脂异常和炎症性疾病有关。辣木叶或绿咖啡豆的提取物被发现可以治疗代谢紊乱，是多酚和类黄酮的良好来源。此外，咖啡是膳食抗氧化剂和绿原酸的丰富来源。本研究旨在探讨辣木(MO)和绿咖啡豆(GC)乙醇提取物对四氧嘧啶诱导的糖尿病大鼠的保护作用，以及不同实验组大鼠的应激氧化、肝肾功能障碍和肝肾组织学改变。采用大鼠胃管给药。结果发现，口服绿咖啡豆和辣木叶乙醇提取物可显著降低糖尿病大鼠28 d后的血糖水平(P < 0.05)，改善血脂、肝功能酶和肾功能。肝组织和肾组织的组织学切片显示MO和GC对大鼠的保护作用。值得注意的是，辣木叶与绿咖啡豆之间存在协同效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Egyptian Journal of Agricultural Sciences

自引率

0.00%

发文量