Energy Efficient Synthesis of various Benzodiazepin-2-ones using Microwave Synthesizer

Jasmin K. Khatri, S. Pednekar, R. Chaughule
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引用次数: 0

Abstract

Benzodiazepine-2-one moiety consists of a seven-membered heterocyclic ring, a derivative of benzodiazepine group, that works in the central nervous system and used for a variety of medical conditions, such as anxiety, seizures and alcohol withdrawal. Microwave assisted synthesis of certain medically important benzodiazepin-2-ones was carried out using hexamine and ammonium chloride starting from 2-aminobenzophenones. Feasibility and optimization of the reaction conditions under closed vessel CEM microwave synthesizer provide the desired product with excellent yields (~90%), within minutes of focused microwave irradiation, without the use of catalyst, thereby, revealing the benefit of saving energy and time.
微波合成器高效合成各种苯二氮卓-2-酮
苯二氮卓-2- 1部分由一个七元杂环组成,是苯二氮卓的衍生物,在中枢神经系统中起作用,用于治疗各种疾病,如焦虑、癫痫发作和戒酒。以2-氨基苯甲酮为起始原料,用二氯氰胺和氯化铵微波辅助合成了某些具有重要医学意义的苯二氮卓-2-酮。密闭容器CEM微波合成器下反应条件的可行性和优化,在不使用催化剂的情况下,在微波集中辐照的几分钟内,以优异的收率(~90%)获得了所需的产物,从而显示出节省能源和时间的好处。
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