Seroepidemiology of human herpesvirus 6 infection in normal children and adults in Spain

Serodiagnosis and Immunotherapy in Infectious Disease Pub Date : 1995-12-01 DOI:10.1016/0888-0786(96)87294-5

C. Roldan, J. Gutierrez, C. Maroto, G. Piedrola

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引用次数: 2

Abstract

We have studied the prevalence of anti-human herpesvirus 6 (HHV-6) antibodies in different population groups from Spain. Serum samples from 271 children between 0 and 15 years old, 512 intravenous drug addicts (IVDA) (262 seropositive for human immunodeficiency virus (HIV)) and 254 healthy individuals (100 pregnant women). The indirect immunofluorescence technique was used for antibody investigation from initial dilutions of 1 : 40. Seroprevalence studies showed antibody presence in 37.6%. The highest positivity was found in the group of children (49.4%, P<0.001), followed by the pregnant women (39%), the IVDAs (34%) and healthy subjects (28%). When the IVDA group was split into HIV positive and HIV negative, no significant difference was found between them (P = 0.45). Antibody titres oscillated between 1 : 40 and 1 : 2560, with the greatest frequency at 1 : 40 in both male and female patients. A statistically significant difference (P < 0.05) was only found between sexes in the control group.

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西班牙正常儿童和成人6型人疱疹病毒感染的血清流行病学研究

我们研究了西班牙不同人群中抗人疱疹病毒6 (HHV-6)抗体的流行情况。血清样本来自271名0至15岁儿童、512名静脉注射吸毒者(IVDA)(262名人类免疫缺陷病毒(HIV)血清阳性)和254名健康个体(100名孕妇)。采用间接免疫荧光技术对1:40初始稀释液进行抗体检测。血清阳性率研究显示抗体阳性率为37.6%。阳性率最高的是儿童组(49.4%，P<0.001)，其次是孕妇组(39%)、ivda组(34%)和健康组(28%)。将IVDA组分为HIV阳性组和HIV阴性组时，两者间无显著性差异(P = 0.45)。抗体滴度在1:40和1:25 60之间振荡，在男性和女性患者中，抗体滴度在1:40的频率最高。统计学上有显著差异(P <0.05)，仅在对照组中存在性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Serodiagnosis and Immunotherapy in Infectious Disease

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