FORMULATION DEVELOPMENT AND CHARACTERIZATION OF NADIFLOXACIN LOADED SOLID LIPID NANOPARTICLE BASED HYDROGEL

Abstract

The aim of this dissertation work was to develop and characterize an optimal formulation of solid lipid nanoparticles of nadifloxacin, which would then be incorporated into hydrogel. The SLN was developed with drug nadifloxacin, which is poorly water soluble. On the basis of solubility studies (i.e. partitioning effects), the lipid and components were chosen. In this study, the two variables amount of lipid and concentration of Poloxamer 188 were studied. The EE increased as the concentration of Poloxamer 188 increased. The particle size was observed to decrease as the concentration of Poloxamer 188 was increased. The EE increased in a similar way as the amount of lipid was increased. So the purpose was to formulate hydrogel with carbopol 940 with improved drug entrapment, sufficient viscosity, good extrudability, good homogeneity and improved drug release. Hydrogels are polymers that have swelling ability in water or aqueous solvent systems. Due to their increased water content, gels can provide a better feeling for skin than other conventional dosage forms. Hydrogels are insoluble in water. They are not easily removed from the application site.