Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report.

IF 1.2 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Women & Health Pub Date : 2023-12-01 Epub Date: 2022-06-15 DOI:10.5507/bp.2022.026

Dominika Ecsiova, Katerina Kamaradova, Marketa Nova, Petr Hoffmann, Petra Rozsivalova, Martin Simkovic, Pavel Zak

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引用次数: 0

Abstract

Background: Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections. Rarely, hairy cell leukemia manifests as a lung infiltration. The differential diagnosis between infection and malignant involvement with hairy cell leukemia is often challenging in such situations.

Methods and results: We present a 53-year-old female with an uncommon pulmonary involvement with hairy cell leukemia. In addition, we discuss the complicated differential diagnosis of pulmonary disease in patients with hairy cell leukemia and the treatment approach to these patients.

Conclusion: This case report describes the successful therapy management of a patient with pulmonary involvement by hairy cell leukemia. Therapy with interferon-alfa and cladribine resulted in long-term remission of the underlying disease.

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毛细胞白血病患者的肺损伤--感染累及还是血液病活动？病例报告。

背景：毛细胞白血病（HCL）是一种罕见的轻度淋巴细胞增生性疾病，患者体内积聚着成熟的 B 淋巴细胞，其染色质呈细网状，细胞质呈典型的毛发样细胞质突起。毛细胞白血病很少表现为肺部浸润。在这种情况下，毛细胞白血病的感染和恶性浸润之间的鉴别诊断往往具有挑战性：我们报告了一名 53 岁女性毛细胞白血病罕见的肺部受累病例。此外，我们还讨论了毛细胞白血病患者肺部疾病的复杂鉴别诊断以及对这些患者的治疗方法：本病例报告描述了毛细胞白血病肺部受累患者的成功治疗。使用干扰素-法和克拉德里滨治疗后，患者的基础疾病得到了长期缓解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Women & Health Multiple-

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Women & Health publishes original papers and critical reviews containing highly useful information for researchers, policy planners, and all providers of health care for women. These papers cover findings from studies concerning health and illness and physical and psychological well-being of women, as well as the environmental, lifestyle and sociocultural factors that are associated with health and disease, which have implications for prevention, early detection and treatment, limitation of disability and rehabilitation.