Transforming Growth Factor-?1 and infertility

Abstract

Abstract: Male infertility is a problem that affects 10–15% of men in reproductive age. The present study aimed to detect the role Transforming Growth Factor-?1 (TGF-?1) cytokine in infertility outpatients’ males at Al-Nasiriya Educational Hospital / Infertility Unit / Thi-Qar Governorate Iraq, during the period from September 2022 to March 2023. Serum samples from 88 (76 infertility males and 12 control) were collected and assayed by Sandwich-ELISA technique. Infertility patients were distributed to Primary and secondary infertility type with a 66(86.84%) and 10(13.016%) patient, respectively (P?0.01). All infertility patients showed an elevated mean sera levels of TGF-?1 with (0.734±0.45 pg/ml), as compared with the controls (0.670± 0.393 pg/ml). No statistical differences were appeared between the two groups included in the present study regarding this cytokine (P>0.05). The study results may shed light the role of TGF-?1 as a serological tool in male infertility.