A Comparative Antihyperlipidemic Activity Of Atorvastatin With Simvastatin In Rats

Abstract

The present study was aimed at comparing the pharmacodynamics of simvastatin (S) with atorvastatin in hyperlipidemic rats. The standard cholesterol diet was used to induce hyperlipidemia in Wister rats. The blood samples were collected from simvastatin and atorvastatin treated rats and analyzed for pharmacodynamics (lipid profiles) of using reported methods. Simvastatin produced a more significant change in lipid profiles than atorvastatin.