Potential Role of Zamzam Water in Some Chronic Diseases in Rats

药学与临床研究 Pub Date : 2017-08-25 DOI:10.25258/IJPCR.V9I08.9582

Amal S. Abdel-Azeem, A. Mubarak, Y. Abd-Elhady, Asmaa Gaber Mohammed Badawi

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引用次数: 3

Abstract

Water from holy zamzam is consumed by many Muslims in the world due to its beneficial role for the health of human beings.Therefore the present study was designed to evaluate the effect of zamzam water in diabetes mellitus, nephrotoxicity and hepatotoxicity in rats as well as to determine the chemical analysis of this water. Fifty six male albino rats weighting (150±5gm) were divided into four main groups and each group was divided into two subgroups a and b, one administered tap water (Tw) and the other subgroup administered zamzam water (zw). The 1st main group was normal rat (-ve control), the 2nd group was diabetic (induced by alloxan 150 mg/kg b.w.), the 3rd was nephrotoxic (induced by gentamicin 100 mg/kg b.w.) and the 4th group was hepatotoxic by carbon tetrachloride (2ml/ kg b.w.). The experiment lasted after four weeks. Zamzam water significantly decreased serum glucose, total lipids, total cholesterol, triglycerides, LDL-cholesterol and elevated HDL- cholesterol. Moreover the liver and kidney markers were also improved in the groups that treated with zamzam water relative to its control taking tap water. Zamzam water has a protective role against hazardous effects of diabetes mellitus, nephrotoxicity and hepatotoxicity in rats.

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赞赞水在大鼠慢性疾病中的潜在作用

世界上许多穆斯林都饮用圣赞赞的水，因为它对人类健康有益。因此，本研究旨在评价赞赞水对糖尿病、大鼠肾毒性和肝毒性的作用，并确定赞赞水的化学分析。将体重(150±5gm)的雄性白化大鼠56只分为4个主要组，每组又分为a、b两个亚组，一个亚组给自来水(Tw)，另一个亚组给扎扎水(zw)。第一主组为正常大鼠(对照组)，第二主组为糖尿病大鼠(四氧嘧啶150 mg/kg b.w诱导)，第三主组为肾毒性大鼠(庆大霉素100 mg/kg b.w诱导)，第四主组为四氯化碳肝毒性大鼠(2ml/ kg b.w)。实验持续了四周。Zamzam水显著降低血清葡萄糖、总脂、总胆固醇、甘油三酯、低密度脂蛋白胆固醇和升高的高密度脂蛋白胆固醇。此外，与饮用自来水的对照组相比，用zamzam水处理的组的肝脏和肾脏标志物也有所改善。赞赞水对大鼠糖尿病、肾毒性和肝毒性具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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药学与临床研究

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