EFFECTIVENESS OF TARA DARA (Catharanthus roseus L.) BOILED WATER TOWARD UREUM LEVELS AND CREATININ RATS OF WISTAR GALUR WALL STRAPS

Rani Meinora Situmeang, Untung Sudharmono
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Abstract

Acute kidney failure is a disorder that occurs suddenly in the ability of the kidneys to infiltrate blood, which is characterized by increased levels of ureum and creatinine within a few days or weeks. This study aims to determine the effectiveness of the tread (Catharanthus roseus L.) on the levels of ureum and creatinine in male wistar strain models of acute kidney failure. The object of the study were 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams per rat. The study was divided into three groups, namely the treatment group, positive control group, and negative control group. Each group consisted of 10 male rats. Tread leaves taken as much as 5.2 grams are boiled in 300 cc of water until the remaining 100 cc of boiled water. The treatment group and positive control group induced gentamicin 12 mg intra peritoneal / rat / day for the second 7 days. The treatment group was given boiled water for as much as 3.6 cc / day orally for 7 days. Giving a gentamicin injection to damage the kidneys. Data collection on urea and creatinine levels was calculated using the SPSS program version 24 One Way ANOVA test to compare creatinine urea levels. The results showed that there were significant differences in creatinine urea levels between the treatment group and the positive control group (p <0.05). This study concludes that the boiled water of the tread (Catharanthus roseus L.) is effective in reducing the level of ureum and creatinine of male rats in the Wistar strain model of acute kidney failure.
塔拉(Catharanthus roseus L.)的有效性沸水对尿水平的影响和对wistar galur壁带大鼠的影响
急性肾衰竭是一种突然发生的肾脏渗透血液的能力紊乱,其特征是在几天或几周内尿和肌酐水平升高。本研究旨在探讨花楸花(Catharanthus roseus L.)对急性肾衰竭雄性wistar株模型的尿和肌酐水平的影响。研究对象为30只2-3月龄雄性Wistar系大鼠,每只大鼠体重180-200克。研究分为三组,即治疗组、阳性对照组和阴性对照组。每组10只雄性大鼠。取5.2克的踏面叶在300cc的水中煮沸,直到剩下的100cc煮沸。治疗组和阳性对照组腹腔注射庆大霉素12 mg /大鼠/ d,连续第2 ~ 7天。治疗组给予开水3.6 cc / d,口服7 d。注射庆大霉素损害肾脏。尿素和肌酐水平的数据收集使用SPSS程序版本24进行单向方差分析,比较肌酐尿素水平。结果显示,治疗组与阳性对照组肌酐尿素水平差异有统计学意义(p <0.05)。本研究认为花楸水对Wistar急性肾衰竭模型雄性大鼠的尿和肌酐水平有降低作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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