Chronic Autoimmune Gastritis: Risk Factors, Clinical Manifestations and Diagnostic Principles

Abstract

This publication summarizes and systematizes the data available in the literature on chronic autoimmune gastritis (CAG) in order to increase the awareness of specialists about the modern possibilities of diagnosing the disease, including in the early stages. Possible variants of the disease clinical manifestation include gastrointestinal, hematological (primarily, the formation of iron deficiency and B12-deficiency anemia), as well as neurological. Patients with CAG are characterized by comorbidity with other autoimmune diseases. Presented the data on the most informative serological markers of the diagnosis of CAG, as well as laboratory tests to detect micronutrient deficiency, information about characteristic changes in the gastric mucosa and the prognosis of the disease. The diagnosis of CAG should be based on a multidisciplinary approach that combines a thorough analysis of patient complaints with a mandatory assessment of nutritional status, the results of serological, endoscopic and histological methods of research