An Integrated Caco-2TC7cells/biosensors Device for the Real Time Monitoring of Intestinal Glucose and Polyphenols Absorption and Hypoglycemic Effect of Phytochemicals

Barberis Antonio , Garbetta Antonella , Cardinali Angela , Bazzu Gianfranco , D’Antuono Isabella , Rocchitta Gaia , Fadda Angela , Linsalata Vito , D’Hallewin Guy , Serra Pier Andrea , Minervini Fiorenza
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Abstract

An integrated device, for real-time monitoring of glucose and phenols absorption, that consists of a sensors/biosensors system (SB) and a Caco-2TC7 human intestinal cell culture, is shown here. The SB was made of a glucose oxidase-based biosensor, a sentinel platinum sensor, a laccase/tyrosinase-based biosensor and a sentinel carbon sensor located in the basolateral compartment (BC) of a cell culture plate. This system was able to monitor the glucose absorption and the hypoglycemic effect induced by different polyphenols and could be proposed to provide an effective strategy to manage postprandial hyperglycemia with natural compounds.

一种集成caco - 2tc7细胞/生物传感器实时监测肠道葡萄糖和多酚吸收及植物化学物质降糖作用的装置
图中展示了一种用于实时监测葡萄糖和酚类吸收的集成设备,该设备由传感器/生物传感器系统(SB)和Caco-2TC7人肠道细胞培养物组成。SB由葡萄糖氧化酶生物传感器、前哨铂传感器、漆酶/酪氨酸酶生物传感器和位于细胞培养板基底外侧室(BC)的前哨碳传感器组成。该系统能够监测不同多酚诱导的葡萄糖吸收和降糖效果,为利用天然化合物控制餐后高血糖提供了有效的策略。
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