Influence of Three Kinds of Traditional Chinese Therapies on Airway Remodeling in Asthmatic Rats

World Science and Technology Pub Date : 2012-08-01 DOI:10.1016/S1876-3553(13)60010-1

Xu Zhaoxia, Li Xueliang, Qian Peng, Li Na, Wang Yiqin, Yan Haixia, Guo Rui, Hao Yiming

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引用次数: 2

Abstract

This paper was aimed at observing the protective effects of traditional Chinese medicine (TCM) varying in therapeutic methods on airway remodeling in bronchial asthma. Three TCM decoctions, representing body resistance-strengthening therapy, lung-diffusing therapy, and combination therapy, were prepared and administrated peroral to asthmatic rats induced by ovalbumin. Eosinophils (EOS) were counted in bronchoalveolar lavage fluid (BALF), and levels of matrix metalloproteinase (MMP-9) and tissue inhibitors of metalloproteinase (TIMP)-1 were detected in serum by ELISA. The results showed that compared with the control group administration of TCM recipes is significantly effective in reducing EOS infiltration into BALF; there was a drop in MMP-1 level and a rise in TIMP-1 level. It was concluded that the three TCM therapies exerted similar protective effects against bronchial asthma. The improvement in airway remodeling can be attributed in part to the inhibiting infiltration of EOS, down-regulating MMP-9 expression and up-regulating TIMP-1 expression.

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三种中药对哮喘大鼠气道重塑的影响

本文旨在观察不同治疗方法中药对支气管哮喘气道重塑的保护作用。制备了三种中药煎剂，分别为体阻法、肺弥散法和联合法，分别给予卵清蛋白诱导的哮喘大鼠口服。测定支气管肺泡灌洗液(BALF)中嗜酸性粒细胞(EOS)， ELISA法检测血清基质金属蛋白酶(MMP-9)和金属蛋白酶组织抑制剂(TIMP)-1水平。结果表明:与对照组相比，中药方剂能显著降低EOS对BALF的浸润;MMP-1水平下降，TIMP-1水平升高。结论:三种中药治疗方法对支气管哮喘的保护作用相似。气道重塑改善的部分原因可能是抑制EOS的浸润，下调MMP-9表达，上调TIMP-1表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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World Science and Technology

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