Lulu Huang, Xiuming Feng, Wenjun Yang, Xiangzhi Li, Kang Zhang, Shuzhen Feng, Fei Wang, Xiaobo Yang
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引用次数: 4
Abstract
BACKGROUND
Various risk factors have been associated with the risk of thyroid cancer in observational studies. However, the causality of the risk factors is not clear given the susceptibility of confounding and reverse causation. A 2-sample Mendelian randomization approach was used to estimate the effect of potential risk factors on thyroid cancer risk.
METHODS
Genetic instruments to proxy 55 risk factors were identified by genome-wide association studies (GWAS). Associations of these genetic variants with thyroid cancer risk were estimated in GWAS of the FinnGen Study (989 cases and 217,803 controls). A Bonferroni-corrected threshold of P=9.09×10 -4 was considered significant, and P<0.05 was considered to be suggestive of an association.
RESULTS
Telomere length was significantly associated with increased thyroid cancer risk after correction for multiple testing (OR=4.68, 95%CI 2.35 to 9.31, P=1.12×10 -5). Suggestive associations with increased risk were noted for waist-to-hip ratio (OR=1.85, 95%CI 1.02 to 3.35, P=0.042) and diastolic blood pressure (OR=1.03, 95%CI 1.00 to 1.06, P=0.040). Suggestive associations were noted between hemoglobin A1c (HbA1c) (OR=0.20, 95%CI 0.05 to 0.82, P=0.025) and decreased risk of thyroid cancer. Risk of thyroid cancer was not associated with sex hormones and reproduction, developmental and growth, lipids, diet and lifestyle, or inflammatory factors (All P>0.05).
CONCLUSION
Our study identified several potential targets for primary prevention of thyroid cancer, including central obesity, diastolic blood pressure, HbA1c, as well as telomere length that should inform public health policy.
期刊介绍:
The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.