Effects of boron compounds and ozonated olive oil on experimental Microsporum canis ınfection in rats

IF 0.5 4区农林科学 Q4 VETERINARY SCIENCES

Turkish Journal of Veterinary & Animal Sciences Pub Date : 2020-03-01 DOI:10.3906/vet-1910-51

Ayhan Hilal Gezer, A. Acar

{"title":"Effects of boron compounds and ozonated olive oil on experimental Microsporum canis ınfection in rats","authors":"Ayhan Hilal Gezer, A. Acar","doi":"10.3906/vet-1910-51","DOIUrl":null,"url":null,"abstract":"This study aimed to investigate the treatment outcomes of topical application of boric acid, boron-doped gel, and ozonated olive oil in cases of Microsporum canis -induced dermatophytosis. Furthermore, the outcomes were compared to those of terbinafine administration. We included 39 female Wistar albino rats weighing 200-250 g and created an M. canis-infected area on the skin of their backs. The rats were clinically scored on days 0, 7, 14, 21, and 28 and underwent histopathological evaluation. All the treated groups demonstrated significantly lower clinical scores than the control group P < 0.05 . Fewer inflammation cells were observed in the samples of groups treated with 3% boric acid and sodium pentaborate pentahydrate gel than in those of the control group. According to the histopathological evaluation, the groups treated with 3% boric acid and sodium pentaborate pentahydrate gel were statistically different from the control and other treatment groups P < 0.05 . Our results indicated that treatment with 3% boric acid and sodium pentaborate gel was adequate in resolving M. canis -induced infection in rats. Therefore, gels containing 3% boric acid and sodium pentaborate pentahydrate may be alternatives to antifungal agents such as terbinafine by ensuring easy, reliable, inexpensive, and effective treatment modalities.","PeriodicalId":23357,"journal":{"name":"Turkish Journal of Veterinary & Animal Sciences","volume":"16 1","pages":"258-265"},"PeriodicalIF":0.5000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Veterinary & Animal Sciences","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3906/vet-1910-51","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 1

Abstract

This study aimed to investigate the treatment outcomes of topical application of boric acid, boron-doped gel, and ozonated olive oil in cases of Microsporum canis -induced dermatophytosis. Furthermore, the outcomes were compared to those of terbinafine administration. We included 39 female Wistar albino rats weighing 200-250 g and created an M. canis-infected area on the skin of their backs. The rats were clinically scored on days 0, 7, 14, 21, and 28 and underwent histopathological evaluation. All the treated groups demonstrated significantly lower clinical scores than the control group P < 0.05 . Fewer inflammation cells were observed in the samples of groups treated with 3% boric acid and sodium pentaborate pentahydrate gel than in those of the control group. According to the histopathological evaluation, the groups treated with 3% boric acid and sodium pentaborate pentahydrate gel were statistically different from the control and other treatment groups P < 0.05 . Our results indicated that treatment with 3% boric acid and sodium pentaborate gel was adequate in resolving M. canis -induced infection in rats. Therefore, gels containing 3% boric acid and sodium pentaborate pentahydrate may be alternatives to antifungal agents such as terbinafine by ensuring easy, reliable, inexpensive, and effective treatment modalities.

查看原文本刊更多论文

硼化合物和臭氧化橄榄油对实验性犬小孢子菌ınfection的影响

本研究旨在探讨局部应用硼酸、硼掺杂凝胶和臭氧化橄榄油治疗犬小孢子虫引起的皮肤癣的效果。此外，将结果与特比萘芬组进行比较。我们选取了39只体重200-250 g的雌性Wistar白化大鼠，并在其背部皮肤上建立了一个犬支原体感染区。分别于第0、7、14、21、28天进行临床评分，并进行组织病理学评价。各治疗组临床评分均显著低于对照组P < 0.05。在用3%硼酸和五水五硼酸钠凝胶处理的组中，观察到的炎症细胞比对照组少。经组织病理学评价，3%硼酸和五水五硼酸钠凝胶治疗组与对照组及其他治疗组比较，差异有统计学意义P < 0.05。我们的结果表明，3%硼酸和五硼酸钠凝胶足以解决大鼠犬支原体感染。因此，含有3%硼酸和五水五硼酸钠的凝胶可以通过确保简单、可靠、廉价和有效的治疗方式来替代特比萘芬等抗真菌药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Turkish Journal of Veterinary & Animal Sciences 农林科学-兽医学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

24 months

期刊介绍： The Turkish Journal of Veterinary and Animal Sciences is published electronically 6 times a year by the Scientific and Technological Research Council of Turkey (TÜBİTAK). Accepts English-language manuscripts on all aspects of veterinary medicine and animal sciences. Contribution is open to researchers of all nationalities. Original research articles, review articles, short communications, case reports, and letters to the editor are welcome. Manuscripts related to economically important large and small farm animals, poultry, equine species, aquatic species, and bees, as well as companion animals such as dogs, cats, and cage birds, are particularly welcome. Contributions related to laboratory animals are only accepted for publication with the understanding that the subject is crucial for veterinary medicine and animal science. Manuscripts written on the subjects of basic sciences and clinical sciences related to veterinary medicine, nutrition, and nutritional diseases, as well as the breeding and husbandry of the above-mentioned animals and the hygiene and technology of food of animal origin, have priority for publication in the journal. A manuscript suggesting that animals have been subjected to adverse, stressful, or harsh conditions or treatment will not be processed for publication unless it has been approved by an institutional animal care committee or the equivalent thereof. The editor and the peer reviewers reserve the right to reject papers on ethical grounds when, in their opinion, the severity of experimental procedures to which animals are subjected is not justified by the scientific value or originality of the information being sought by the author(s).