Suppressive effect of dietary resistant maltodextrin on systemic immunity in a mouse model of food allergy

IF 3.1 4区医学 Q2 Agricultural and Biological Sciences

Bioscience of Microbiota, Food and Health Pub Date : 2019-03-06 DOI:10.12938/bmfh.18-025

S. Miyazato, Masato Tsuda, Y. Kishimoto, A. Hosono

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引用次数: 4

Abstract

Resistant maltodextrin (RMD) is a soluble dietary fibre that exerts several physiological functions as a result of its microbial degradation and changes in the intestinal environment. It has been reported that RMD enhanced immunoglobulin A (IgA) secretion, which protects the mucosa from foreign substances. However, the effect of RMD on excessive immunity has yet to be investigated. In this study, we aimed to investigate the effect of RMD on excessive immune responses such as food allergy. OVA23-3 mice were fed an AIN-76-based diet containing 20% egg-white protein with or without RMD. While RMD was shown to contribute to an increase in goblet cells, RMD did not change the overall inflammatory status when ingested with the egg-white diet. RMD suppressed IL-4 and IL-10 production from splenocytes but not cells from mesenteric lymph nodes. RMD also downregulated the serum levels of OVA-specific Th1- and Th2-related antibodies, which were elevated in the food-allergic condition. RMD significantly increased the total amount of short-chain fatty acids, especially acetate and propionate, in the caecum of OVA23-3 mice fed the egg-white diet. Our study demonstrated that dietary RMD modulates systemic rather than intestinal antigen-specific immune responses in the food-allergic condition of OVA23-3 mice. Although the relevant mechanism has yet to be investigated, RMD shows potential for alleviating food allergy through adjustment of systemic immunity.

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耐药麦芽糖糊精对食物过敏小鼠全身免疫的抑制作用

耐药麦芽糊精(RMD)是一种可溶性膳食纤维，由于其微生物降解和肠道环境的变化而发挥多种生理功能。据报道，RMD增强免疫球蛋白A (IgA)的分泌，保护粘膜免受外来物质的侵害。然而，RMD对过度免疫的影响还有待研究。在本研究中，我们旨在研究RMD对食物过敏等过度免疫反应的影响。OVA23-3小鼠分别饲喂含20%蛋清蛋白的以ain -76为基础的饲粮，并添加或不添加RMD。虽然RMD被证明有助于杯状细胞的增加，但当与蛋清饮食一起摄入时，RMD并没有改变整体炎症状态。RMD抑制脾细胞产生IL-4和IL-10，但对肠系膜淋巴结细胞没有抑制作用。RMD还下调了ova特异性Th1-和th2相关抗体的血清水平，这些抗体在食物过敏条件下升高。RMD显著提高了饲喂蛋清日粮的OVA23-3小鼠盲肠中短链脂肪酸的总量，尤其是乙酸和丙酸。我们的研究表明，在OVA23-3小鼠的食物过敏条件下，膳食RMD调节的是全身而不是肠道抗原特异性免疫反应。虽然相关机制尚未研究，但RMD显示出通过调节全身免疫来减轻食物过敏的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

5.50

自引率

3.20%

发文量

期刊介绍： Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.