Comparison of Visual Rating Scale Based on Brain 18F-FDG-PET and Montreal Cognitive Assessment Test in Probable Alzheimer’s Disease

IF 0.3 4区医学 Q4 Medicine

Acta Medica Mediterranea Pub Date : 2022-06-13 DOI:10.32552/2022.actamedica.740

E. Aladağ, E. Bulut, Pınar Demirayak, Bilge Volkan Salancı, K. Karlı Oğuz, B. Erbaş, E. Ergün, B. B. Doğu, M. Cankurtaran, M. Halil

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引用次数: 0

Abstract

Objecives: Recently, imaging biomarkers like flouro-deoxi-glucose positron emission tomography (FDG-PET) become even more important for evaluation probable AD. The aim of this study was to evaluate the possible correlation between Montreal Cognitive Assessment Test (MoCA) and metabolic function of brain regions determined by FDG-PET in patients with probable AD. Materials and methods: Thirty seven (37) patients who had diagnosis of probable AD were included. MoCA test and metabolic measurements of brain regions by FDG-PET were performed in all patients. A visual scoring was performed to obtain the rates of hypometabolism in brain regions.Results: Median age of the patients was 77 (minimum 65-maximum 83) years. On the right hemisphere, MOCA test score decreased according to visual FDG-PET score of parietal lobe (15±5.1, 11.8±8.4 and 8.5±5.9; p=0.032). MOCA test score was 16±5.8, 13.1±7.6 and 9.1±6.1 in patients with left temporal lobe and 15.2±5.2, 11.8±7.8 and 8.5±5.9 in patients with left parietal lobe according to visual FDG-PET scores respectively (p=0.035; p=0.02). The comparison of the other right and left hemisphere regions and MOCA test scores were not significant.Conclusion: The present study is emphasized that the MoCA test which is easily applied in outpatient clinics can be demonstrated the hypometabolism of bilateral parietal and left temporal brain regions related with pathophysiology of AD.

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基于脑18F-FDG-PET的视觉评定量表与蒙特利尔认知评估测验在可能的阿尔茨海默病中的比较

目的:最近，像氟脱氧葡萄糖正电子发射断层扫描(FDG-PET)这样的成像生物标志物在评估可能的AD方面变得越来越重要。本研究的目的是评估蒙特利尔认知评估测试(MoCA)与FDG-PET测定的疑似AD患者脑区代谢功能之间可能的相关性。材料与方法:入选37例疑似AD的患者。所有患者均进行MoCA检测和FDG-PET脑区代谢测定。通过视觉评分来获得大脑区域的低代谢率。结果:患者中位年龄为77岁(最小65-最大83岁)。根据顶叶FDG-PET视觉评分，右半球MOCA评分降低(15±5.1、11.8±8.4和8.5±5.9);p = 0.032)。左侧颞叶MOCA评分分别为16±5.8、13.1±7.6和9.1±6.1，左侧顶叶MOCA评分分别为15.2±5.2、11.8±7.8和8.5±5.9 (p=0.035;p = 0.02)。其他左右半球区域和MOCA测试分数的比较无显著性。结论:本研究强调易于在门诊应用的MoCA试验可以显示与AD病理生理相关的双侧顶叶和左颞叶脑区代谢低下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Mediterranea 医学-医学：内科

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Medica Mediterranea is an indipendent, international, English-language, peer-reviewed journal, online and open-access, designed for internists and phisicians. The journal publishes a variety of manuscript types, including review articles, original research, case reports and letters to the editor.