Evaluation of the Relationship between Capillaroscopic Symptoms and the Severity of Systemic Lupus Erythematous

IF 1.8 4区医学 Q3 PATHOLOGY

International Journal of Experimental Pathology Pub Date : 2022-08-30 DOI:10.33696/pathology.3.037

F. Shirani, Leila Barahimi

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引用次数: 0

Abstract

Objectives: Use of imaging tools can detect some specific pathological changes associated with systemic lupus erythematous (SLE). This study aimed to investigate the relationship between capillaroscopic symptoms and the severity of SLE. Methods: This was a cross-sectional study carried out on 56 patients with SLE undergoing capillaroscopy referred to Rasool-e Akram hospital in Tehran in 2018. Capillaroscopy findings were assessed according to demographic characteristics and duration of disease. Results: All patients had at least one positive finding related to capillaroscopy. Regarding capillaroscopic findings, abnormal microvascular structure in 37.5%, decreased vascular density in 78.6%, enlarged cap loop in 32.1%, microhemorrhage in 16.1% and neoangiogenesis in 25.0% were observed. The results revealed higher vascular density loss in women and higher neoangiogenesis in affected men and higher rate of abnormal microvascular structure at older ages and microhemorrhage at younger ages. Direct relationship was also found between duration of disease and microhemorrhage. Conclusion: Almost all patients with SLE undergoing capillaroscopy had at least one pathophysiological change in the capillary bed. The most common pathophysiological change was decreased vascular density, abnormal microvascular structure and capillary loop enlargement.

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评价毛细血管镜下症状与系统性红斑狼疮严重程度的关系

目的:利用影像学工具可以发现与系统性红斑狼疮(SLE)相关的一些特定病理改变。本研究旨在探讨毛细血管镜下症状与SLE严重程度之间的关系。方法:这是一项横断面研究，对2018年在德黑兰Rasool-e Akram医院接受毛细血管镜检查的56例SLE患者进行了研究。根据人口统计学特征和疾病持续时间评估毛细血管镜检查结果。结果:所有患者至少有一项与毛细管镜检查相关的阳性发现。微血管镜检查结果:微血管结构异常占37.5%，血管密度下降占78.6%，帽环增大占32.1%，微出血占16.1%，新生血管生成占25.0%。结果显示，女性的血管密度损失更高，男性的新生血管生成更高，老年人微血管结构异常率更高，年轻时微血管出血率更高。病程与微出血也有直接关系。结论:几乎所有接受毛细血管镜检查的SLE患者毛细血管床至少有一种病理生理改变。最常见的病理生理变化是血管密度降低、微血管结构异常和毛细血管袢增大。

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来源期刊

International Journal of Experimental Pathology 医学-病理学

CiteScore

4.50

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Pathology encompasses the use of multidisciplinary scientific techniques to investigate the pathogenesis and progression of pathologic processes. The International Journal of Experimental Pathology - IJEP - publishes papers which afford new and imaginative insights into the basic mechanisms underlying human disease, including in vitro work, animal models, and clinical research. Aiming to report on work that addresses the common theme of mechanism at a cellular and molecular level, IJEP publishes both original experimental investigations and review articles. Recent themes for review series have covered topics as diverse as "Viruses and Cancer", "Granulomatous Diseases", "Stem cells" and "Cardiovascular Pathology".