UTILIZATION OF MICROWAVE ASSISTED BLACK CUMIN SEED EXTRACT AS HYPOCHOLESTEROLEMIC AGENT IN ALBINO RATS

A. A. Khalil, Ahood Khalid, H. Khalid, A. Aslam, QuratulAin Shahid, Miroslava Hlebová, M. Rebezov, M. Derkho, M. Shariati
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引用次数: 1

Abstract

Main aim of this study was to evaluate hypocholesterolemic potential of microwave-assisted black cumin (Nigella sativa) extracts (MABCEs) in a rat bioassay. Efficacy trial in this study comprised of 25 male albino rats which were divided into 5 groups having 5 rats each. Out of these 25 rats, 20 were hypercholesterolemic and 5 were normal rats. Hypercholesterolemia was induced by providing high cholesterol diet for 15 days, and after the onset of hypercholesterolemia these rats were administered with different concentrations of the MABCE i.e. 150, 300 & 450 mg/kg B.W. for a period of 28 days. The administration of extract displayed significant lowering in the lipid profile of the experimental rats. The 300mg/kg B.W. dose of black cumin MAE provided the optimum results giving cholesterol, triglyceride and LDL-c content lowered by 14.9%, 11.32% and 12% and value of HDL-c elevated by 12.88% compared to the hypercholesterolemic control. Similarly, there was a percent elevation in levels of SOD and CAT by 19.83% and 13.97%. The current study concluded that MABCEs have hypocholesterolemic effect thus can be used for its therapeutic property.
微波辅助黑孜然籽提取物在白化病大鼠降胆固醇剂中的应用
本研究的主要目的是评价微波辅助黑孜然提取物(MABCEs)在大鼠生物测定中的降胆固醇潜能。本研究疗效试验选用雄性白化大鼠25只,分为5组,每组5只。在这25只大鼠中,20只是高胆固醇血症大鼠,5只是正常大鼠。高胆固醇饮食诱导高胆固醇血症15天,在高胆固醇血症发生后给予不同浓度的MABCE,即150、300和450 mg/kg体重,持续28天。给药后,大鼠血脂明显降低。与高胆固醇血症对照组相比,300mg/kg体重剂量的黑孜然MAE可使胆固醇、甘油三酯和LDL-c含量分别降低14.9%、11.32%和12%,HDL-c值升高12.88%。同样,SOD和CAT的水平升高了19.83%和13.97%。目前的研究表明,MABCEs具有降低胆固醇的作用,因此可以用于其治疗特性。
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