Gambaran Makroskopis Persembuhan Luka Mukosa Buccal Tikus Putih (Rattus norvegicus) Pascapemberian Policresulen

ARSHI Veterinary Letters Pub Date : 2021-04-02 DOI:10.29244/avl.4.3.57-58

Tribhuana Tunggadewi, Tony Wahyudi, Aisyah Alviatus Shofwan, Anggri Azhari Khoerunnisa, H. S. Darusman

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Abstract

This study aimed to investigate the effect of policresulen treatment with various concentrations on the wound healing in buccal mucosa of white rats (Rattus norvegicus) through macroscopically observation. The number of 54 rats were divided into six treatment groups policresulen with concentration of 36%, 10%, 5%, 1%, 0.3% and one control group. The buccal mucosal injury was made with a 0.5 cm biopsy punch. The treatment of mucosal injury was conducted by dropped policresulen on the 2nd day until the 5th day after the injury. Macroscopic observation under a stereo micro-scope was conducted on the wound diameter, redness, swelling, and necrose. The results showed that wound healing was influenced significantly with concentration of the policresulen. The best healing was shown on lowest concentration marked which has lowest size of the wound diameter (0.50 ± 0.00 cm), the lowest tissue redness (0.00 ± 0.00), lowest final swelling at a concentration of 0.3%. Clinical evaluation of wound tissue necrose parameters which were seen to be most severe at 10% policresulen administration followed by 36% concentration and the least necrose shown on policresulen administration 0.3%. Therefore, based on macroscopic images with parameters of wound diameter, redness, swelling, and necrose suggested that policresulen used for wound healing process are at a concentration of 0.3%.

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本研究旨在通过宏观观察，探讨不同浓度的甘草素对褐家鼠口腔黏膜创面愈合的影响。将54只大鼠分为浓度为36%、10%、5%、1%、0.3%的6个治疗组和1个对照组。口腔黏膜损伤用0.5 cm穿刺活检。粘膜损伤的治疗于损伤后第2天至第5天滴注胶凝。在立体显微镜下对创面直径、红肿、坏死进行宏观观察。结果表明，甘草多糖浓度对伤口愈合有显著影响。创面直径最小(0.50±0.00 cm)，组织红度最小(0.00±0.00)，最终肿胀最小(0.3%)，愈合效果最佳。伤口组织坏死参数的临床评价结果显示，10%的浓度下伤口组织坏死最严重，其次是36%的浓度，0.3%的浓度下伤口组织坏死最少。因此，根据伤口直径、红肿、坏死等参数的宏观图像提示，用于伤口愈合过程的政治性果素浓度为0.3%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ARSHI Veterinary Letters

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