Quantitative Reference Ranges for Fasting Profiles and Oral Glucose Tolerance Test for Healthy Adults in Metropolitan Region of Nairobi, Kenya

S. Waithaka, Enm Njagi, J. Ngeranwa, D. M. Mwangi, Bernard M. Chiuri, L. Njagi, W. Gatua
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引用次数: 2

Abstract

Purpose: To establish quantitative reference ranges for fasting profiles and oral glucose tolerance test for healthy adults in metropolitan region of Nairobi. Methods: A prospective study carried out on 871 healthy subjects from the metropolitan region of Kenya. Results: The fasting profile parameters investigated were fasting blood glucose (FBG), total cholesterol (TC) triglycerides (TG), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC) and TC/HDLC ratio. In addition, oral glucose tolerance test (OGTT) was also investigated. Eight hundred and seventy one (871) healthy study subjects were involved in the study. Established reference ranges were as follows: FBG (venous whole blood) (2.1 – 5.7) mmol/L, TC (2.9 – 6.4) mmol/L, TG (0.44- 2.44), HDL C (1.1 – 2.1) mmol/L, LDLC (1.1 – 4.3) mmol/L, TC/HDLC ratio (1.1 – 5.4). Established reference ranges for oral glucose tolerance test (OGTT) were as follows: baseline/fasting blood glucose capillary whole blood (3.2-5.4) mmol/L, half hour (4.7-8.9) mmol/L, one hour (4.4-9.8) mmol/L, one hour and half (4-8.1) mmol/L and two hours (3.4-7.2) mmol/L. Results for gender differences for the studied parameters were as follows: FBG (p=0.124), TC (p=0.205), TG (p=0.705) HDLC (p= 0.52), LDLC (p=0.417) and TC/HDLC ratio (p=0.359). On the other hand, the gender results for timed OGTT were as follows: 0 hour (p=0.123), half hour (p=0.479), one hour (p=0.412), one hour and half (p=0.596)) and two hours (p=0.630). Hence there were no gender disparities for the parameters in the studied adult Kenyan population. Conclusion: Since the established reference ranges are a reflection of the Kenyan adult population our clinical chemistry laboratory reports interpretations will henceforth be independent of what has been quoted in literature. Likewise effective diagnosis and management of glucose and lipids pathological disorders will be achieved by the use of established adult Kenyan reference ranges. Keywords: Reference ranges, lipid profile, fasting blood glucose, Adult Kenyan, Nairobi metropolitan city
肯尼亚内罗毕市区健康成人空腹和口服葡萄糖耐量试验定量参考范围
目的:建立内罗毕市区健康成人空腹谱和口服糖耐量试验的定量参考范围。方法:对来自肯尼亚大都市区的871名健康受试者进行前瞻性研究。结果:研究空腹血糖(FBG)、总胆固醇(TC)甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)和TC/HDLC比值。此外,还进行了口服葡萄糖耐量试验(OGTT)。871名健康受试者参与了这项研究。建立的参考范围为:FBG(静脉全血)(2.1 ~ 5.7)mmol/L, TC (2.9 ~ 6.4) mmol/L, TG (0.44 ~ 2.44), HDLC (1.1 ~ 2.1) mmol/L, ldl (1.1 ~ 4.3) mmol/L, TC/HDLC比值(1.1 ~ 5.4)。口服糖耐量试验(OGTT)的参考范围为:基线/空腹血糖毛细血管全血(3.2 ~ 5.4)mmol/L、半小时(4.7 ~ 8.9)mmol/L、1小时(4.4 ~ 9.8)mmol/L、1小时半(4 ~ 8.1)mmol/L、2小时(3.4 ~ 7.2)mmol/L。研究参数的性别差异如下:FBG (p=0.124)、TC (p=0.205)、TG (p=0.705)、HDLC (p= 0.52)、LDLC (p=0.417)和TC/HDLC比值(p=0.359)。另一方面,时间OGTT的性别结果如下:0小时(p=0.123),半小时(p=0.479), 1小时(p=0.412), 1小时半(p=0.596))和2小时(p=0.630)。因此,在研究的肯尼亚成年人口中,这些参数没有性别差异。结论:由于建立的参考范围是肯尼亚成年人口的反映,因此我们的临床化学实验室报告的解释将从此独立于文献中引用的内容。同样,有效的诊断和管理葡萄糖和脂质病理性疾病将通过使用既定的肯尼亚成人参考范围来实现。关键词:参考范围,血脂,空腹血糖,肯尼亚成年人,内罗毕大都市
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