Length of Disease More than Therapy Impacts Anxiety and Depression in Multiple Sclerosis

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
P. McLaughlin, L. Odom, P. Arnett, G. Thomas, Shannon Orehek, I. Zagon
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Abstract

Persons with multiple sclerosis (PwMS) often report a reduced quality of life related to their anxiety and depression associated with the biological unknowns of MS. The COVID-19 pandemic increased the risk of anxiety due to the uncertainties related to vaccine efficacy and immune-suppressing disease-modifying therapies. PwMS were recruited from the Neurology Clinic of the Penn State Hershey Medical Center and asked to complete a demographic questionnaire and surveys on depression (MS-Beck Depression Inventory, MS-BDI) and the Hospital Anxiety and Depression Scale (HADS). The rationale for the study is to determine whether treatment modalities, age, and length of disease impacted anxiety and/or depression in PwMS. Data from 150 participants were included in the analyses. The overall mean age was 54.6 years with a 3.7:1 female:male ratio and mean length of disease of approximately 17 years. Mean scores of the HADS-D, and high scores (> 8) were 4.68 ± 0.3 and 10.0 ± 0.32, respectively, with no differences between males and females. The mean HADS-A score was 6.15 ± 0.36 with significant differences recorded between male and females. The mean high HADS-A score was 10.77 ± 0.40, with no differences between sexes. The mean MS-BDI score was 4.15 ± 0.7 with no differences between males and females. Analyses of anxiety scores in relationship to length of disease revealed no differences between males and females. Anxiety scores did not differ for PwMS on different disease-modifying therapies. In conclusion, the number of years that PwMS had the disease impacted anxiety levels more than the age or treatment regimen..
病程长短对多发性硬化症患者焦虑和抑郁的影响大于治疗
多发性硬化症(PwMS)患者经常报告生活质量下降,这与他们的焦虑和抑郁有关,这与ms的生物学未知因素有关。COVID-19大流行增加了焦虑的风险,因为疫苗疗效和免疫抑制疾病修饰疗法存在不确定性。研究人员从宾夕法尼亚州立好时医学中心神经病学门诊招募了PwMS,并要求他们完成人口统计问卷和抑郁调查(MS-Beck抑郁量表,MS-BDI)和医院焦虑和抑郁量表(HADS)。该研究的基本原理是确定治疗方式、年龄和疾病持续时间是否会影响PwMS患者的焦虑和/或抑郁。来自150名参与者的数据被纳入分析。总体平均年龄为54.6岁,男女比例为3.7:1,平均病程约为17年。HADS-D平均评分为4.68±0.3分,高分(> 8分)为10.0±0.32分,男女差异无统计学意义。平均HADS-A评分为6.15±0.36,男女差异有统计学意义。平均HADS-A高分为10.77±0.40,性别差异无统计学意义。MS-BDI平均评分为4.15±0.7,男女差异无统计学意义。焦虑得分与疾病长度的关系分析显示,男性和女性之间没有差异。不同疾病改善疗法对PwMS患者的焦虑评分没有差异。总之,PwMS患病年数对焦虑水平的影响大于年龄或治疗方案。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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