Effect Of Methanolic Leaves Extract of Telfairia occidentalis on 2,4-Dinitrophenylhydrazine Induced Anaemic Rats

Z. Sulaiman, Y. Salahuddeen, U. Sabiu
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Abstract

Anaemia constitutes a serious health problem in many tropical countries including Nigeria because of the high prevalence of malaria and other parasitic infections which possibly leads to a decrease in hemoglobin. Fluted pumpkin has been reported to be very good in building the constituents of the blood and replacing them. This study investigated the effects of the methanolic leaves extract of fluted pumpkin on some hematological parameters in 2, 4-dinitrophenylhydrazine-induced anaemic rats. Thirty Wister rats of both sexes were separated into five groups of six rats each. Group 1 serves as normal control, while groups 2-5 were induced with anaemia using 40mg/kg body weight of 2,4- dinitrophenylhydrazine. Group 2 serves as the negative control without treatment, group 3 were given 20 mg/kg (b.w) of standard hematinic drug astymin, and group 4 and 5 were administered with 200 and 400 mg/kg w/w methanolic leaves extract of Telfairia occidentals respectively. All rats were fed with grower’s mash and water ad libitum for 21 days. The rats were sacrificed, and blood samples were collected for hematological analysis. All analysis was done using standard methods. The result of this study demonstrated that oral administration of 200 mg/kg and 400mg/kg of the extract increased the haematological parameters under investigation. A significant (p<0.05) increase in haematinic activity was observed in group 3 and 5, and it was concluded that methanolic leaves extract of fluted pumpkin could be effective in ameliorating anaemia. Keywords: Anemia; Telfairia occidentalis; 2, 4-dinitrophenylhydrazine; Haematological
西洋参叶甲醇提取物对2,4-二硝基苯肼致贫血大鼠的影响
在包括尼日利亚在内的许多热带国家,贫血是一个严重的健康问题,因为疟疾和其他寄生虫感染的高流行率可能导致血红蛋白下降。据报道,有凹槽的南瓜在构建血液成分和替换它们方面非常好。研究了南瓜叶甲醇提取物对2,4 -二硝基苯肼致贫血大鼠血液学指标的影响。30只雌雄Wister大鼠被分成五组,每组6只。第1组为正常对照,第2 ~ 5组以2,4-二硝基苯肼40mg/kg体重诱导贫血。2组为阴性对照,不作任何处理,3组给予标准血药天冬氨酸20 mg/kg (b.w), 4组和5组分别给予冬冬叶甲醇提取物200和400 mg/kg w/w。各组大鼠分别饲喂种植者醪液和水,饲喂21 d。处死大鼠,采集血样进行血液学分析。所有分析均采用标准方法进行。本研究结果表明,口服200 mg/kg和400mg/kg的提取物增加了所研究的血液学参数。第3组和第5组血液活性显著(p<0.05)升高,说明槽南瓜甲醇叶提取物有改善贫血的作用。关键词:贫血;Telfairia occidentalis;2、4-dinitrophenylhydrazine;血液学的
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