Study Of Prevalence Of Pulmonary Hypertension In Chronic Kidney Disease And Its Co-Relation With Clinical & Biochemical Parameters.

Abstract

-OBJECTIVES: The objectives of this prospective observational study were to study (i) the prevalence of pulmonary hypertension (PH) in patients who are on conservative management, haemodialysis or continuous ambulatory peritoneal dialysis, (ii) the co-relation of PH with variables such as A-V fistula, hypertension, diabetes Mellitus & duration for dialysis, and (iii) the co-relation of PH with biochemical parameters.MATERIALS AND METHODS: The study was conducted in a tertiary care centre in Mumbai over a period 12 months after obtaining approval from the Institutional Ethics Committee. 245 CKD patients, on conservative management, haemodialysis and continuous ambulatory peritoneal dialysis were enrolled in this study, taking into consideration the inclusion & exclusion criteria and appropriate informed consent after taking detailed history of every patient. All patients underwent routine investigations and 2D ECHO for pulmonary hypertension. RESULTS: Our study enrolled 245 patients in the age group of 20 to 85 years where 68.6% patients were male and 31.4% were females. 28.2% patients had CKD with PH while 71.8% had CKD without PH. The proportion of patients with PH having AV fistula was significantly more than those without AV fistula. Of the 28.2% patients with PH, 33.6% had hypertension and 22% were diabetic. Our study revealed a positive association between the duration of dialysis and the prevalence of PH along-with low levels of haemoglobin and serum bicarbonate, and high levels of uric acid, BUN and creatinine. CONCLUSION: The prevalence of PH was found to be 28.2%. PH is positively correlated with chemical as well as biochemical parameters.