Clinical value of INSS/INRGSS staging of peripheral neuroblastictumors in children

Q4 Medicine

中华小儿外科杂志 Pub Date : 2019-11-15 DOI:10.3760/CMA.J.ISSN.0253-3006.2019.11.007

Chen Chenjun, D. Juan, Zhu Haobo, W. Lixia, Gu Yunfei

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引用次数: 0

Abstract

Objective To explore the role of International Neuroblastoma Staging System (INSS) or International Neuroblastoma Risk Group Staging System (INGRSS) in peripheral neuroblastic tumors. Methods From 2006 to 2018, a retrospective analysis was performed for 108 peripheral neuroblastictumors (pNT) children.There were 62 boys and 46 girls.All of them were operated and pathological examinations conducted.However, 4 s/Ms staged cases were excluded.Analyses were performed with regards to age, weight distribution, pathological results, INSS/INRGSS stage, neuron-specific enolase (NSE), lactate dehydrogenase (LDH), lesion size, image-defined risk factors (IDRFs), operative duration and tumor index.The relationship between stage and complete removal was explored. Results No statistically significant inter-gender difference existed in the distribution between tumors and the age of neuroblastoma (NB) was younger.The specific pathologies were NB (n=68), ganglioneuroblastoma (GNB, n=30) and ganglioneuroma (GN, n=10). No significant difference existed in the distribution of INSS/INRGSS staging.NSE and LDH values of pNTs with diameters >5 cm and L2 & M phases spiked sharply.The number of IDRFs was higher in NB than GNB.And pNT patients with diameters >10 cm, stages L2 & M and positive IDRFs had a longer operative duration and a lower probability of complete resection. Conclusions The preoperative evaluations of INSS/INRGSS staging for pNT offer more advantages than INSS staging alone.It may guide the choice of specific treatments.The presence or absence of IDRFs is an important factor for a complete removal of tumors. Key words: Neuroblastoma; Peripheral neuroblastictumors; Ganglioneuroblastoma; Ganglioneuroma

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儿童周围神经母细胞肿瘤INSS/INRGSS分期的临床价值

目的探讨国际神经母细胞瘤分期系统(INSS)或国际神经母细胞瘤危险分组分期系统(inggrss)在周围神经母细胞瘤中的作用。方法对2006年至2018年收治的108例儿童周围神经母细胞瘤(pNT)进行回顾性分析。有62名男孩和46名女孩。所有患者均行手术和病理检查。然而，4 s/Ms阶段的病例被排除在外。对年龄、体重分布、病理结果、INSS/INRGSS分期、神经元特异性烯醇化酶(NSE)、乳酸脱氢酶(LDH)、病变大小、图像定义危险因素(idrf)、手术时间和肿瘤指数进行分析。探讨了阶段与完全去除的关系。结果不同性别间肿瘤分布无统计学差异，神经母细胞瘤(NB)年龄越小。具体病理为NB (n=68)、神经节神经母细胞瘤(GNB, n=30)和神经节神经瘤(GN, n=10)。INSS/INRGSS分期分布差异无统计学意义。直径>5 cm的pnt和L2、M相的NSE和LDH值急剧上升。NB的idrf数量高于GNB。直径>10 cm、L2和M期及idrf阳性的pNT患者手术时间较长，完全切除的可能性较低。结论术前评价INSS/INRGSS分期比单独进行INSS分期更有优势。它可以指导具体治疗方法的选择。IDRFs的存在与否是肿瘤完全切除的重要因素。关键词:神经母细胞瘤;外围neuroblastictumors;Ganglioneuroblastoma;星形胶质细胞瘤

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来源期刊

中华小儿外科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.40

自引率

0.00%

发文量

8707

期刊介绍： Chinese Journal of Pediatric Surgery is an academic journal sponsored by the Chinese Medical Association. It mainly publishes original research papers, reviews and comments in this field. The journal was founded in 1980 and is included in well-known databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences) and CSCD Chinese Science Citation Database Source Journal (including extended version). It is one of the national key academic journals under the supervision of the China Association for Science and Technology. Chinese Journal of Pediatric Surgery enjoys a high reputation and influence in the academic community. The articles published in this journal have a high academic level and practical value, providing readers with a large number of practical cases and industry information, and have received widespread attention and citations from readers.