Reference values and biological determinants for cardiac myosin-binding protein C concentrations assessed with an enzyme-linked immunosorbent assay.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-10-27 DOI:10.5937/jomb0-39081

Sylwester M Kloska, Marek Kozinski, Anna Stefanska, Katarzyna Bergmann, Aneta Mankowska-Cyl, Joanna Siodmiak, Grazyna Sypniewska, Magdalena Krintus

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引用次数: 0

Abstract

Background: Cardiac myosin-binding protein C (cMyC) is a novel cardio-specific biomarker of potential diagnostic and prognostic value for cardiovascular events. This study aims to determine reference values for cMyC and identify biological determinants of its concentration.

Methods: A population of 488 presumably healthy adults were enrolled to define biological determinants which affect cMyC concentrations in serum. Concentrations of cMyC were assessed using enzyme-linked immunosorbent assays from commercially available kits. Eligibility for inclusion in this study evaluated all subjects' anthropometric, demographic and laboratory measurements. After applying strict inclusion criteria, a reference population (n=150) was defined and used to determine reference values. Reference values were derived using a robust method.

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用酶联免疫吸附试验评估心脏肌球蛋白结合蛋白 C 浓度的参考值和生物学决定因素。

背景：心脏肌球蛋白结合蛋白 C（cMyC）是一种新型心血管特异性生物标志物，对心血管事件具有潜在的诊断和预后价值。本研究旨在确定 cMyC 的参考值，并确定其浓度的生物学决定因素：方法：研究人员招募了 488 名假定健康的成年人，以确定影响血清中 cMyC 浓度的生物决定因素。使用市售试剂盒中的酶联免疫吸附测定法评估 cMyC 的浓度。本研究对所有受试者的人体测量、人口统计学和实验室测量结果进行了评估。在采用严格的纳入标准后，确定了参考人群（n=150）并用于确定参考值。参考值采用稳健的方法得出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.