{"title":"Efek Rebusan Sereh (Cymbopogon citratus) Terhadap Respon Stress Oksidatif Pada Tikus Wistar Jantan (Rattus norvegicus) Diabetes","authors":"Barinta Widaryanti, Nurul Khikmah, Nunung Sulistyani","doi":"10.15294/lifesci.v10i2.54457","DOIUrl":null,"url":null,"abstract":"Diabetes mellitus is a metabolic disorder with hyperglycemia. The amount of diabetic patients in Indonesia will increase rapidly without suitable treatment. High level of blood glucose will trigger oxidative stress. The objective of this research wa to investigate the effect of lemongrass on oxidative stress response that was indicated by serum and hepatic Total antioxidant capacity and Malondialdehyde level. Thirty male wistar rat were divided into five groups. K1 was a normal group, K2 was a normal group with lemongrass treatment, K3 was a diabetic group induced by a single dose of Streptozotocin at a concentration of 60 mg/kg body weight, K4 was a diabetic group that was treated with glibenclamid at a concentration of 0.09 mg/200 gr body weight, while K5 was a diabetic group treated with lemongrass at a concentration of 3.6 ml/200 gr body weight. The result showed that lemongrass was able to reduce blood glucose levels, serum MDA and hepatic MDA levels and increased the level of total antioxidant status \n \nDiabetes adlah kelainan metabolisme yang ditandai dengan hiperglikemia. Jumlah penderita diabetes mellitus di Indonesia akan mengalami peningkatan jika tidak ada penanganan yang sesuai. Tinggi kadar glukosa darah dapat memicu terjadinya stress oksidatif. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian sereh terhadap respon stress oksidatif yang ditunjukan dengan kapasitas antioksidan total dan kadar malondialdehid. Tigapuluh ekor tikus wistar jantan dibagi menjadi lima kelompok. K1 adalah kelompok normal, K2 adalah kelompok normal dengan perlakuan sereh, K3 adalah kelompok diabetes yang diinduksi dengan streptozotocin 60 mg/kg berat badan single dose, K4 adalah kelompok diabetes yang diberi perlakuan dengan glibenklamid dengan dosis 0.09 mg/200 gr berat badan. Sedangkan K5 adalah kelompok diabetes yang dieri perlakuan dengan rebusan sereh dengan dosis 3.6 ml/200 gr berat badan. Hasil penelitian menunjukan bahwa rebusan sereh mampu menurunkan kadar glukosa darah, konsetrasi malondialdehid serum dan hepar, serta meningkatkan total antioksidan status pada serum dan hepar. ","PeriodicalId":49909,"journal":{"name":"Life Science Journal","volume":"32 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life Science Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15294/lifesci.v10i2.54457","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetes mellitus is a metabolic disorder with hyperglycemia. The amount of diabetic patients in Indonesia will increase rapidly without suitable treatment. High level of blood glucose will trigger oxidative stress. The objective of this research wa to investigate the effect of lemongrass on oxidative stress response that was indicated by serum and hepatic Total antioxidant capacity and Malondialdehyde level. Thirty male wistar rat were divided into five groups. K1 was a normal group, K2 was a normal group with lemongrass treatment, K3 was a diabetic group induced by a single dose of Streptozotocin at a concentration of 60 mg/kg body weight, K4 was a diabetic group that was treated with glibenclamid at a concentration of 0.09 mg/200 gr body weight, while K5 was a diabetic group treated with lemongrass at a concentration of 3.6 ml/200 gr body weight. The result showed that lemongrass was able to reduce blood glucose levels, serum MDA and hepatic MDA levels and increased the level of total antioxidant status
Diabetes adlah kelainan metabolisme yang ditandai dengan hiperglikemia. Jumlah penderita diabetes mellitus di Indonesia akan mengalami peningkatan jika tidak ada penanganan yang sesuai. Tinggi kadar glukosa darah dapat memicu terjadinya stress oksidatif. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian sereh terhadap respon stress oksidatif yang ditunjukan dengan kapasitas antioksidan total dan kadar malondialdehid. Tigapuluh ekor tikus wistar jantan dibagi menjadi lima kelompok. K1 adalah kelompok normal, K2 adalah kelompok normal dengan perlakuan sereh, K3 adalah kelompok diabetes yang diinduksi dengan streptozotocin 60 mg/kg berat badan single dose, K4 adalah kelompok diabetes yang diberi perlakuan dengan glibenklamid dengan dosis 0.09 mg/200 gr berat badan. Sedangkan K5 adalah kelompok diabetes yang dieri perlakuan dengan rebusan sereh dengan dosis 3.6 ml/200 gr berat badan. Hasil penelitian menunjukan bahwa rebusan sereh mampu menurunkan kadar glukosa darah, konsetrasi malondialdehid serum dan hepar, serta meningkatkan total antioksidan status pada serum dan hepar.
糖尿病是一种伴有高血糖的代谢性疾病。如果没有适当的治疗,印度尼西亚的糖尿病患者数量将迅速增加。高血糖会引发氧化应激。本研究旨在探讨柠檬草对大鼠血清和肝脏总抗氧化能力及丙二醛水平的影响。将30只雄性wistar大鼠分为5组。K1为正常组,K2为柠檬草处理的正常组,K3为单剂量链脲佐菌素诱导的糖尿病组,浓度为60 mg/kg体重,K4为格列本脲治疗的糖尿病组,浓度为0.09 mg/200克体重,K5为柠檬草处理的糖尿病组,浓度为3.6 ml/200克体重。结果表明,柠檬草能够降低血糖水平、血清MDA和肝脏MDA水平,并提高总抗氧化状态水平。糖尿病,糖尿病,糖尿病,糖尿病,糖尿病,糖尿病,糖尿病丁基kadar - glukosa - dara - dapa - mema - jadinya - stress - okatiti。图鹃penelitian ini adalah untuk mengetahui pengaruh pemberian serhad对应力的反应,yang ditunjukan dengan kapasitas antioksidan total dan kadar malondialdeh。Tigapuluh ekor tikus wistar jantan dibagi menjadi lima kelompok。K1 adalah kelpok正常、K2 adalah kelpok正常、K3 adalah kelpok糖尿病阳diindukki登干链脲佐菌素60 mg/kg白藜芦醇单剂量、K4 adalah kelpok糖尿病阳diberi perlakkan登干格列本酰胺登干剂量0.09 mg/200 g白藜芦醇。Sedangkan K5 adalah kelompok糖尿病杨dieri perlakuan dengan rebusan sereh dengan剂量3.6 ml/200 g / badan。脑膜肯总抗氧化酶和血清抗氧化酶状态。
期刊介绍:
Life Science Journal, the Acta Zhengzhou University Oversea Version, is an international journal with the purpose to enhance our natural and scientific knowledge dissemination in the world under the free opinion/idea publishing principle. The journal is calling for papers from all the world. All the valuable papers or reports that are related to life sciences - in their broadest sense - are welcome. Other academic articles that are only certain relevant but are of high quality will also be considered and published. Papers submitted could be reviews, objective descriptions, research reports, opinions/debates, news, letters, and other types of writings. All submitted manuscripts will be sent for external peer review and processed the editorial work. After the peer review, the journal will make the best efforts to publish the accepted valuable articles as soon as possible. Let''s work together to disseminate our research results and our opinions/ideas.