Microwave Assisted Synthesis and QSAR Study of 1-Substituted-3-aryl-1H-pyrazole-4-carbaldehydes Derivatives

Abstract

Several 1-substituted-3-aryl-1H-pyrazole-4-carbaldehyde (3a-g) derivatives were synthesized by substituted acetophenone (1a-d), substituted hydrazine (2a-b) and DMF in POCl3 and reaction mixture was irradiated with microwave at 20% power to furnish 1-substituted-3-aryl-1H-pyrazole-4-carbaldehydes derivatives (3a-g).