Acupressure combined with pharmacological treatment in patients with osteoarthritis of the knee: a randomized trial

IF 1.7 Q2 Medicine
Meenu Rani, Lokendra Sharma, Uma Advani
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引用次数: 2

Abstract

Objectives

To test the effect of noninvasive self-performed acupressure therapy as an add-on to pharmacological treatment to manage knee main and to evaluate the improvement of pain due to intervention according to age and body mass index.

Methods

In the study, 240 participants were assigned into three groups (1) KAP group (verum acupressure and pharmacological treatment) (2) Comparison Group 1 (sham acupressure and pharmacological treatment), and (3) Comparison Group 2 (pharmacological treatment only). Outcome measures were subscales of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual analog scale and 36-item Short-Form Health Survey. Intention–to–treat analysis was used and missing data was deal with multiple imputation method. The general linear mixed model was carried out to assess the differences between the study groups at different durations (3 months, 6 months, and 1 year).

Results

Compared with CG-1 and CG-2, participants of the KAP group reported considerable improvements in WOMAC pain (mean difference: −2.50 units; 95% CI, 3.74–1.25, and mean difference: −1.69 units; 95%CI, −3.24 to −0.13 respectively) at 1 year. Similarly, VAS pain, stiffness, and physical function were also improved among the participants of KAP group.

Conclusion

Self-administered acupressure has an additive effect to the pharmacological treatment to improve pain, stiffness, and physical function as compared to pharmacological treatment only.

穴位按压联合药物治疗膝关节骨关节炎患者:一项随机试验
目的观察无创自行穴位按摩疗法在药物治疗的基础上治疗膝关节疼痛的效果,并根据年龄和体重指数评价干预后疼痛的改善情况。方法将240名受试者随机分为3组(1)KAP组(穴位按压加药物治疗)(2)比较1组(假穴位按压加药物治疗)和(3)比较2组(仅药物治疗)。结果测量采用西安大略和麦克马斯特大学骨关节炎指数(WOMAC)亚量表、视觉模拟量表和36项简短健康调查。采用意向处理分析,并用多重插值法处理缺失数据。采用一般线性混合模型评估研究组在不同持续时间(3个月、6个月和1年)的差异。结果与CG-1和CG-2相比,KAP组的参与者报告了WOMAC疼痛的显著改善(平均差异:−2.50单位;95% CI为3.74-1.25,平均差值为- 1.69个单位;95%CI,分别为- 3.24至- 0.13)。同样,KAP组VAS疼痛、僵硬和身体功能也得到改善。结论与单纯药物治疗相比,自我穴位按压对药物治疗有改善疼痛、僵硬和身体功能的附加作用。
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来源期刊
Advances in integrative medicine
Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.20
自引率
11.80%
发文量
0
审稿时长
15 weeks
期刊介绍: Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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