Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas.

IF 6.3 2区医学 Q1 ONCOLOGY

Neoplasia Pub Date : 2008-09-17 DOI:10.1055/S-0028-1089530

L. Grochola, T. Greither, H. Taubert, P. Möller, U. Knippschild, A. Udelnow, D. Henne-Bruns, P. Würl

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引用次数: 9

Abstract

Telomerase is thought to play an essential role in tumorigenesis and progression. Its activity is directly correlated with the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT). A correlation of transcript expression with a poor prognosis has been detected in different human malignancies. However, data on hTERT in pancreatic ductal adenocarcinoma (PDAC) are purely descriptive so far. Therefore, we evaluated the impact of hTERT expression on patients' prognosis. Human telomerase reverse transcriptase mRNA isolates from 56 human microdissected PDAC tissues were analyzed by quantitative reverse transcription-polymerase chain reaction and multivariate Cox regression hazard test. Elevated hTERT transcript levels were measured in 23 of 56 PDAC tissues, 33 patients showed no detectable transcripts. Unexpectedly, a low expression of hTERT mRNA levels was associated with a worse prognosis for overall survival (relative risk = 5.33; P = .013) when compared to high levels, whereas undetectable expression showed an intermediate risk of tumor-related death. These data challenge previous findings outlining hTERT's negative impact on overall survival. The risk pattern obtained in PDAC suggests a more complex regulation of hTERT.

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胰腺导管腺癌中hTERT mRNA表达与预后的相关性。

端粒酶被认为在肿瘤发生和发展中起重要作用。其活性与其催化亚基——人端粒酶逆转录酶(hTERT)的表达直接相关。在不同的人类恶性肿瘤中发现了转录表达与预后不良的相关性。然而，到目前为止，hTERT在胰腺导管腺癌(PDAC)中的数据纯粹是描述性的。因此，我们评估了hTERT表达对患者预后的影响。采用定量逆转录-聚合酶链反应和多因素Cox回归危害检验对56例人PDAC微解剖组织中分离的人端粒酶逆转录酶mRNA进行分析。56例PDAC组织中有23例检测到hTERT转录物水平升高，33例患者未检测到转录物。出乎意料的是，hTERT mRNA水平的低表达与总生存预后较差相关(相对风险= 5.33;P = 0.013)，而无法检测到的表达显示肿瘤相关死亡的中等风险。这些数据挑战了先前关于hTERT对总体生存的负面影响的发现。在PDAC中获得的风险模式表明hTERT的监管更为复杂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neoplasia ONCOLOGY-

自引率

2.10%

发文量

期刊介绍： Neoplasia publishes the results of novel investigations in all areas of oncology research. The title Neoplasia was chosen to convey the journal’s breadth, which encompasses the traditional disciplines of cancer research as well as emerging fields and interdisciplinary investigations. Neoplasia is interested in studies describing new molecular and genetic findings relating to the neoplastic phenotype and in laboratory and clinical studies demonstrating creative applications of advances in the basic sciences to risk assessment, prognostic indications, detection, diagnosis, and treatment. In addition to regular Research Reports, Neoplasia also publishes Reviews and Meeting Reports. Neoplasia is committed to ensuring a thorough, fair, and rapid review and publication schedule to further its mission of serving both the scientific and clinical communities by disseminating important data and ideas in cancer research.

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