Results of treatment of endometrial hyperplasia with the use of non-steroidal anti-inflammatory agents against the background of chronic endometritis and without accompanying inflammatory process

Abstract

The paper examines the treatment results of women with non-atypical hyperplastic endometrial processes with the use of anti-inflammatory drugs for a long time. The purpose of our study was to evaluate the effectiveness of the proposed treatment regimen depending on the type of hyperplastic processes and their connection with chronic inflammatory processes in the endometrium. Material and methods. We examined 101 women, of which 29 women with hyperplastic processes without accompanying chronic endometritis were included in experimental group №1, 49 women with a combination of hyperplastic processes and chronic endometritis were included in experimental group №2, the control group included 23 women with hyperplastic processes without chronic endometritis. The control group received only hormonal therapy, the experimental group №1 received long-term anti-inflammatory nonsteroidal drugs in addition to hormonal correction, the experimental group №2 received a course of broad-spectrum antibiotics in addition to anti-inflammatory drugs. Treatment effectiveness was evaluated 6, 12 and 24 months after hysteroscopy.Results of the study. 24 months after hysteroscopy in the control group, we observed 43.5% recurrence of hyperplastic endometrial processes, while at the same time when using anti-inflammatory therapy with non-steroidal drugs (experimental group No. 1), after 24 months we observed 20.7% recurrence ( p<0.05) and in women with a combination of GE and HE (experimental group No. 2) with the use of anti-inflammatory nonsteroidal drugs and antibiotics, the relapse rate was 22.4% (p<0.05). The results of additional studies and the use of statistical methods have proven that the effectiveness of treatment is related to the applied methods and is not accidental.Conclusions. The use of non-steroidal anti-inflammatory drugs increases the effectiveness of anti-recurrence conservative treatment of women with hyperplastic processes after hysteroscopy.