Y. Wen, Zhi-feng Zhang, Ning-ning Liu, Yu-hong Xiang, Zhuo-yong Zhang, G. Andrei, R. Snoeck, D. Schols, Qingshan Zhang, Qin-pei Wu
{"title":"Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides","authors":"Y. Wen, Zhi-feng Zhang, Ning-ning Liu, Yu-hong Xiang, Zhuo-yong Zhang, G. Andrei, R. Snoeck, D. Schols, Qingshan Zhang, Qin-pei Wu","doi":"10.1080/15257770.2015.1115523","DOIUrl":null,"url":null,"abstract":"ABSTRACT A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.","PeriodicalId":19306,"journal":{"name":"Nucleosides, Nucleotides and Nucleic Acids","volume":"5 1","pages":"147 - 160"},"PeriodicalIF":0.0000,"publicationDate":"2016-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleosides, Nucleotides and Nucleic Acids","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/15257770.2015.1115523","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
ABSTRACT A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.
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