Magnesium Enhances the Antidiabetic Activity of Lippia multiflora Aqueous Leaves Extract on Redox Status in Streptozotocin-diabetic Rats

Scholars Academic Journal of Pharmacy Pub Date : 2023-01-07 DOI:10.36347/sajp.2023.v12i01.001

B. Konan, Marie Louise Ahui Bitty, Yapo Fulgence Allo, J. Datté

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引用次数: 1

Abstract

Objective: This study was conducted in order to evaluate the antioxidant effects of Lippia multiflora aqueous extract supplemented with magnesium in diabetic rats. Méthodes: 7 groups of 4 STZ-diabetic rats received separately the Glucophage® (Glu 10 mg/kg), the plant aqueous extract (LiMAE 200-600 mg/kg) and the plant aqueous extract supplemented with magnesium (LiMAE-Mg 200-600 mg/kg) in comparison to healthy rats and untreated diabetic rats. After 21 days of daily treatment, activities of enzymes-markers of oxidative stress were measured on kidney and pancreas samples. Results: The occurrence of diabetes induced a significant increase in MDA and a significant decrease in CAT, SOD and GSH in rats. Separate treatment of animals with LiMAE and LiMAE-Mg significantly restored at p < 0.0001 and in a dose-dependent manner the activities and levels of enzymes-markers of oxidative stress. This restoration was greater with LiMAE-Mg, the aqueous extract of Lippia multiflora supplemented with magnesium. LiMAE-Mg very significantly restored the studied parameters with measured values statistically close to normal. Conclusion: The results showed the antidiabetic potential of Lippia multflora extract supplemented with magnesium on oxidative stress.

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镁对链脲佐菌素糖尿病大鼠氧化还原状态的影响

目的:探讨加镁多连皮水提物对糖尿病大鼠的抗氧化作用。实验方法:7组4只stz -糖尿病大鼠分别给予Glucophage®(Glu 10 mg/kg)、植物水提物(LiMAE 200-600 mg/kg)和植物水提物添加镁(LiMAE- mg 200-600 mg/kg)，与健康大鼠和未治疗的糖尿病大鼠比较。每天处理21天后，测量肾脏和胰腺样品氧化应激标志物酶的活性。结果:糖尿病的发生导致大鼠MDA显著升高，CAT、SOD、GSH显著降低。单独使用LiMAE和LiMAE- mg处理动物可显著恢复氧化应激标志物酶的活性和水平(p < 0.0001)，且呈剂量依赖性。在多花Lippia水提物中添加镁的LiMAE-Mg修复效果更好。LiMAE-Mg非常显著地恢复了研究参数，测量值在统计上接近正态。结论:多连皮提取物加镁对氧化应激有一定的抗糖尿病作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Scholars Academic Journal of Pharmacy

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