Evaluation of Invitro and Invivo Antioxidant Activity of Oscillatoria annae

Abstract

In the present study, the ethanol extract of Oscillatoria annae is evaluated for invitro and invivo antioxidant activity. The extract exhibited concentration dependendent 1, 1-diphenyl -2picryl-hydrazyl (DPPH), nitric oxide and hydroxyl radical scavenging activity with IC50 values of 80 μg/ml, 220μg/ml and107.5μg/ml. Further, the protective effect of ethanol extract of Oscillatoria annae against carbon tetrachloride induced oxidative damage was evaluated in albino wistar rats. The results of the Invivo study revealed that, pretreatment with ethanol extract of Oscillatoria annae in doses 200mg/kg and 400mg/kg orally enhanced the tissue superoxide dismutase (SOD), Catalase (CAT), glutathione peroxidase (GPx), Glutathione (GSH) and Glutathione reductase (GR). The results obtained in the present study indicate that ethanol extract of Oscillatoria annae can be a potential source of natural antioxidant activity.