Haemato-pathological effect of dichlorvos on blood picture and liver cells of albino rats

Abstract

The effect of intraperitonal exposure of dichlorvos an organophosphate (OP) pesticide, on haematology parameters and liver pathology of Wister rats was investigated.  Thirty male albino rats grouped into six (6) of five rats each were injected with 0, 3.7, 7.4, 11.1, 14.8 and 18.5mg/kg of dichlorvos (DDVP) (1 ml/kg) respectively. The haematological parameters measured were red blood cells, haemoglobin; packed cell volume, total white blood cells count and platelet levels. Histological examination of liver tissue was investigated as well. The result of the haematological parameters of the dichlorvos treated rats showed a significant decrease (p<0.05) in the mean values of red blood cells, haemoglobin and packed cell volume and a significant increase (p<0.05) in the total white blood cell count and platelet count which was dose dependent. Changes observed in the liver architecture of the treated rat tissues were feathery looks, fatty changes and centrilobular necrosis. However there was no architectural distortion observed in the liver tissue of the control rats. Dichlorvos had dose dependent target toxicity. Key words: Liver, toxicity, dichlorvos, pestiscides, haematology.