Rectal Cancer Perforation: A Rare Complication Of Neo-Adjuvant Radiotherapy For Rectal Cancer

A. Khan, Y. Suhaibani, A. Sharief
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引用次数: 6

Abstract

Purpose: Despite having a well established role in the treatment of locally advanced rectal cancer neoadjuvant radiotherapy is associated with various acute but usually self limited side effects, which can be occasionally severe thus outweighing the potential benefits.Method: We present a case of 51-year old male who experienced a spontaneous rectal perforation after neoadjuvant radiotherapy for transmural (T3) rectal cancer located 8cms from anal verge. Clinical circumstances were highly suggestive of acute radiation toxicity leading to tumor perforation. To our knowledge, such a complication of radiotherapy is extremely rare, albeit known with only few cases reported in English literature.Conclusion: Rectal cancer perforation, albeit rare, is a dangerous early complication of neo-adjuvant radiotherapy for transmural rectal cancer which may be worthy of consideration and discussion with the patient when commencing treatment. Role of prophylactic diverting colostomy in such patients with cancer above peritoneal reflection remains an open question which needs to be redressed by further studies.
直肠癌穿孔:直肠癌新辅助放疗中一种罕见的并发症
目的:尽管新辅助放疗在局部晚期直肠癌的治疗中具有良好的作用,但它与各种急性但通常是自限性的副作用相关,这些副作用有时可能很严重,因此超过了潜在的益处。方法:我们报告了一例51岁男性经新辅助放疗后自发性直肠穿孔的经壁(T3)直肠癌,位于肛门边缘8cm处。临床情况高度提示急性辐射毒性导致肿瘤穿孔。据我们所知,这种放疗并发症是极其罕见的,尽管在英语文献中只有少数病例报道。结论:直肠癌穿孔虽然罕见,但却是经壁直肠癌新辅助放疗的早期危险并发症,值得患者在开始治疗时考虑和讨论。预防性转移结肠造口术在这类腹膜上反射癌患者中的作用仍然是一个悬而未决的问题,需要进一步的研究来解决。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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