Suggested Two Hypotheses on Dementia (“Anticholinergic Hypothesis” and “Cranial Skeletal Muscles Hypothesis”) and the Therapeutic Agent

A. Numazawa
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引用次数: 0

Abstract

The present study was conducted with the objective of further developing the cholinergic hypothesis and not using the prevalent amyloid beta plaque hypothesis or the tau protein hypothesis on dementia. The experiment was conducted on mice using anticholinergic drugs scopolamine and biperiden to investigate the root cause of dementia. First, we measured the mice serum for liquid chromatography-tandem mass spectrometry (LC-MS/MS) after administration of scopolamine and biperiden and found an accumulation of anticholinergic drugs metabolites in the body. The Y-maze test and measurement of LC-MS/MS in the cranial skeletal muscle cells showed that the Scopolamine metabolites have a significant effect on the cranial skeletal muscles, leading to the conclusion that Methocarbamol is an effective treatment for dementia.
提出痴呆的两种假说(“抗胆碱能假说”和“颅骨骼肌假说”)和治疗剂
本研究的目的是进一步发展胆碱能假说,而不是使用流行的淀粉样斑块假说或tau蛋白假说。本实验在小鼠身上使用抗胆碱能药物东莨菪碱和双倍藤来研究痴呆的根本原因。首先,我们用液相色谱-串联质谱法(LC-MS/MS)检测给药后的小鼠血清,发现抗胆碱能药物代谢物在体内积累。y型迷宫试验和颅骨骼肌细胞LC-MS/MS测定表明,东莨菪碱代谢物对颅骨骼肌有显著影响,从而得出甲氨甲酚是治疗痴呆的有效药物的结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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