Raman studies on anticancer inorganic ring -DNA interactions

Abstract

A Raman investigation of pentaziridinocyclodiphosphathiazene -DNA interactions in vitro suggests that the alkylating sites on DNA for this powerful antitumour agent are essentially the oxygen atoms of the ribose backbone with a second order dialkylating effect on the N(7) and $\text{N}$H₂ positions of Adenine. These contrasts with the case of hexaziridinocyclotriphosphazene which interacts with the DNA by the same two routes but through a balanced mode.