SPECTROPHOTOMETRIC DETERMINATION OF MIRTAZAPINE IN PURE AND TABLET PHARMACEUTICAL PREPARATION

Abstract

SUMMARY Sensitive spectrophotometric method was developed for the determination of mirtazapine from pharmaceutical preparats. The proposed method was based on the formation of a yellow colored ion-pair complex by the reaction of methyl orange with mirtazapine. The ion pair complex was extracted with dichloromethane. Under the optimum condition, the ion pair complex showed an absorption maximum at 427 nm. The linearity range for concentrations of mirtazapine was found to be 2.5-12.5 I¼g/mL. The proposed method is successfully applied to the determination of mirtazapine tablet formulations. OZET Mirtazapinin farmasotik preparatlarda tayini icin duyarli spektrofotometrik bir yontem gelistirilmistir. Gelistirilen yontem, mirtazapin ile metil oranj arasinda sari renkli iyon cifti kompleksi olusturmasi esasina dayanmaktadir. Iyon cifti kompleksi diklormetan ile ekstre edilmistir. Optimize edilmis kosullarda iyon cifti kompleksinin maksimum absorbsiyon degeri 427 nm olarak tespit edilmistir. Mirtazapinin dogrusallik araligi 2.5-12.5 I¼g/mL olarak bulunmustur. Gelistirilen yontemin tabletlerde mirtazapin miktar tayininde guvenle uygulanabilir. Key words: Mirtazapine, ion pair complex, spectrophotometry, methyl orange