Medication Exposure Patterns in Primary Care Patients Prescribed Pharmacogenetically Actionable Opioids.

IF 1.6 Q2 SOCIAL SCIENCES, INTERDISCIPLINARY
Mitchell R. Knisely, J. Carpenter, M. Broome, A. Holmes, Diane Von Ah, T. Skaar, C. Draucker
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引用次数: 0

Abstract

Current approaches to assessing medication exposure fail to capture the complexity of the phenomenon and the context in which it occurs. This study's purpose was to develop a typology of subgroups of patients who share common patterns of medication exposure. To create the typology, we used an exemplar sample of 30 patients in a large public healthcare system who had been prescribed the pharmacogenetically actionable opioids codeine or tramadol. Data related to medication exposure were drawn from large data repositories. Using a person-oriented qualitative approach, eight subgroups of patients who shared common patterns of medication exposure were identified. The subgroups had one of five opioid prescription patterns (i.e., singular, episodic, switching, sustained, multiplex), and one of three types of primary foci of medical care (i.e., pain, comorbidities, both). The findings reveal medication exposure patterns that are dynamic, multidimensional, and complex, and the typology offers an innovative approach to assessing medication exposure.
初级保健患者的药物暴露模式处方药理学上可操作的阿片类药物。
目前评估药物暴露的方法未能捕捉到这种现象的复杂性及其发生的背景。本研究的目的是发展一个亚组的患者谁共享药物暴露的共同模式的类型。为了创建类型学,我们使用了一个大型公共医疗保健系统中30名患者的样本,这些患者被开了药理学上可行的阿片类药物可待因或曲马多。与药物暴露相关的数据来自大型数据库。采用以人为本的定性方法,确定了具有共同药物暴露模式的8个患者亚组。这些亚组具有五种阿片类药物处方模式中的一种(即,单一,发作,转换,持续,多重),以及三种主要医疗护理类型中的一种(即,疼痛,合并症,两者)。研究结果揭示了药物暴露模式是动态的、多维的和复杂的,类型学为评估药物暴露提供了一种创新的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Qualitative Report
Qualitative Report SOCIAL SCIENCES, INTERDISCIPLINARY-
CiteScore
2.60
自引率
18.20%
发文量
148
审稿时长
45 weeks
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