Pulmonary function in infants with congenital diaphragmatic hernia

Q4 Medicine

中华小儿外科杂志 Pub Date : 2020-01-15 DOI:10.3760/CMA.J.ISSN.0253-3006.2020.01.006

Weipeng Wang, Wei Xie, Quanhua Liu, Weihua Pan, J. Yi, Wang Yi, Jianhua Zhang, Jun Wang

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引用次数: 0

Abstract

Objective To assess the pulmonary function recovery of infants with congenital diaphragmatic hernia (CDH). Methods The medical records were retrospectively reviewed for CDH infants receiving pulmonary function test (PFT) from November 2016 to March 2019. The relevant data included lung function, follow-up time, gender, sideness of hernia, Apgar score, birth weight, location of liver, admission arterial blood gas analysis, duration of mechanical ventilation and length of hospital stay. Results Forty-five infants were included for analysis. There were 19 boys and 26 girls. And the involved side was left (n=39) and right (n=6). PFT was performed for a total of 89 cases. The mean age at PFT was (9.3±7.3) months. And the frequency of PFT was once (n=20) and twice and more (n=25). Pulmonary function was normal (n=7, 15.6%) and abnormal (n=38, 84.4%). The results were normal pulmonary function (n=10), airflow obstruction (n=62), mixed ventilatory dysfunction (n=11) and airflow restriction (n=6). Significant correlation existed between lung function and age at PFT, sideness of hernia and liver herniation (all P<0.05). Compared with counterparts with airflow restriction, those with airflow obstruction had a later age of PFT [(8.9±6.9) vs.(1.3±05) months, P=0.001]. As compared with previous indices, percent of expiratory time to peak tidal time and percent of tidal volume to peak tidal expiratory flow increased subsequently. Conclusions Pulmonary function abnormality is present in some CDH survivors after repairing. Lung function may be correlated with age at PFT, sideness of hernia and liver herniation. Key words: Hernia, diaphragmatic; Pulmonary function; Follow-up

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先天性膈疝患儿肺功能的研究

目的探讨新生儿先天性膈疝(CDH)肺功能恢复情况。方法回顾性分析2016年11月至2019年3月接受肺功能检查(PFT)的CDH患儿的病历。相关数据包括肺功能、随访时间、性别、疝侧边性、Apgar评分、出生体重、肝脏位置、入院动脉血气分析、机械通气时间、住院时间。结果纳入45例婴儿进行分析。有19个男孩和26个女孩。受累侧分别为左侧(n=39)和右侧(n=6)。共对89例患者行PFT。PFT时平均年龄为(9.3±7.3)个月。PFT发生频率为1次(n=20)， 2次及以上(n=25)。肺功能正常(n=7, 15.6%)，异常(n=38, 84.4%)。结果肺功能正常(n=10)，气流阻塞(n=62)，混合性通气功能障碍(n=11)，气流受限(n=6)。肺功能与PFT年龄、疝侧边、肝疝均有显著相关(P<0.05)。与气流受限组相比，气流阻塞组PFT发病年龄晚[(8.9±6.9)个月比(1.3±05)个月，P=0.001]。与之前的指标相比，呼气时间与潮峰时间的百分比、潮量与潮峰呼气流量的百分比均有所增加。结论部分CDH修复后存在肺功能异常。肺功能可能与PFT年龄、疝侧边及肝疝有关。关键词:疝;膈肌;肺功能;后续

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来源期刊

中华小儿外科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.40

自引率

0.00%

发文量

8707

期刊介绍： Chinese Journal of Pediatric Surgery is an academic journal sponsored by the Chinese Medical Association. It mainly publishes original research papers, reviews and comments in this field. The journal was founded in 1980 and is included in well-known databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences) and CSCD Chinese Science Citation Database Source Journal (including extended version). It is one of the national key academic journals under the supervision of the China Association for Science and Technology. Chinese Journal of Pediatric Surgery enjoys a high reputation and influence in the academic community. The articles published in this journal have a high academic level and practical value, providing readers with a large number of practical cases and industry information, and have received widespread attention and citations from readers.