Efficacy of Probiotics in Improving Motor Function and Alleviating Constipation in Parkinson's Disease: A Randomized Controlled Trial.

IF 23.6 1区心理学 Q1 PSYCHOLOGY

Annual review of psychology Pub Date : 2023-09-01 eCollection Date: 2023-01-01 DOI:10.5812/ijpr-137840

Nasibeh Ghalandari, Farhad Assarzadegan, Seyed Amir Hassan Habibi, Hadi Esmaily, Habib Malekpour

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Abstract

Background: Parkinson's disease (PD) is one of the common neurodegenerative diseases, and there has been an increasing interest in the potential role of intestinal dysbiosis in its pathogenesis and related gastrointestinal complications such as constipation.

Objectives: This study aims to evaluate the effects of multi-strain probiotics on constipation and motor function in PD patients.

Methods: This study was a blinded, randomized controlled trial (RCT) that involved 27 PD patients who were diagnosed with constipation according to the ROME IV criteria for functional constipation. The primary outcome measured before and after the intervention in both the placebo and probiotic groups was the frequency of defecation. Secondary outcomes evaluated were laxative use, sense of complete evacuation, Bristol Stool Scale for consistency, and Unified Parkinson's Disease Rating Scale (UPDRS) scale. The study lasted for eight weeks. Both groups also were educated about lifestyle modification.

Results: Of 30 included patients (15 in each group), 13 were women, and 17 were men. Three patients dropped out of the study. Between-group analysis showed that the frequency of bowel movements significantly increased in the probiotic group 4 [3 - 5] in comparison with 2 [2 - 3] in placebo (P = 0.02). Stool consistency also improved in the probiotic group (P = 0.04). However, there were no significant differences in other outcomes. The within-group analysis showed improvement in stool consistency in both probiotics and placebo groups (P = 0.01 and P = 0.007, respectively), while stool frequency and sense of complete evacuation significantly improved only in the probiotic group (P < 0.05).

Conclusions: This study demonstrated that multi-strain probiotics could improve frequency, consistency, and sense of complete evacuation in PD patients, while there was no significant effect on motor functions in 8 weeks. It is suggested that additional studies be conducted on longer-term effects.

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益生菌在改善帕金森病患者运动功能和缓解便秘方面的功效：随机对照试验

背景：帕金森病（PD）是常见的神经退行性疾病之一，人们越来越关注肠道菌群失调在其发病机制和相关胃肠道并发症（如便秘）中的潜在作用：本研究旨在评估多菌株益生菌对帕金森病患者便秘和运动功能的影响：这项研究是一项盲法随机对照试验（RCT），共有27名根据ROME IV功能性便秘标准被诊断为便秘的PD患者参与。安慰剂组和益生菌组在干预前后的主要结果都是排便次数。次要评估结果包括泻药使用量、完全排空感、布里斯托粪便一致性量表和统一帕金森病评分量表（UPDRS）。研究为期八周。两组患者都接受了有关改变生活方式的教育：在纳入的 30 名患者中（每组 15 人），13 人为女性，17 人为男性。有 3 名患者退出了研究。组间分析显示，益生菌组的排便次数明显增加了 4 [3 - 5]，而安慰剂组为 2 [2 - 3]（P = 0.02）。益生菌组的大便稠度也有所改善（P = 0.04）。不过，其他结果没有明显差异。组内分析显示，益生菌组和安慰剂组的大便一致性都有所改善（P = 0.01 和 P = 0.007），而只有益生菌组的大便次数和完全排空感有显著改善（P < 0.05）：本研究表明，多菌株益生菌可改善帕金森氏症患者的大便次数、粘稠度和完全排空感，但在8周内对运动功能无明显影响。建议对长期效果进行更多研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of psychology 医学-心理学

CiteScore

47.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Psychology, a publication that has been available since 1950, provides comprehensive coverage of the latest advancements in psychological research. It encompasses a wide range of topics, including the biological underpinnings of human behavior, the intricacies of our senses and perception, the functioning of the mind, animal behavior and learning, human development, psychopathology, clinical and counseling psychology, social psychology, personality, environmental psychology, community psychology, and much more. In a recent development, the current volume of this esteemed journal has transitioned from a subscription-based model to an open access format as part of the Annual Reviews' Subscribe to Open initiative. As a result, all articles published in this volume are now freely accessible to the public under a Creative Commons Attribution (CC BY) license.