Systemic endothelium damage and its functional consequences under the action of injuries and infectious agents

Q4 Medicine

Otorhinolaryngology Clinics Pub Date : 2023-01-30 DOI:10.37219/2528-8253-2022-6-02

D. Zabolotnyi, T. Shidlovskaya, Julia V. Dieieva, L. Petruk, M.I. Bezega, S. Verevka

{"title":"Systemic endothelium damage and its functional consequences under the action of injuries and infectious agents","authors":"D. Zabolotnyi, T. Shidlovskaya, Julia V. Dieieva, L. Petruk, M.I. Bezega, S. Verevka","doi":"10.37219/2528-8253-2022-6-02","DOIUrl":null,"url":null,"abstract":"Topicality: Blockage of hemorrhage due to vascular damage is the leading role of the clotting cascade of the hemostasis system. Recently, two types of such damage have become highly relevant. The first of them is caused by viral damage to the endothelium, which leads to uncontrolled cascade activation of the descending system. The second type is caused by aquabarotrauma and associated hydrodynamic shock. Both types of damage lead to the development of thrombotic-fibrous complications of the circulatory system due to the formation of long fibrin deposits. Such deposits are resistant to the action of the fibrinolytic system due to their irregular and chaotic structure. This, in turn, leads to severe functional complications.\nAim: Systematize data on molecular and cellular features of systemic damage to the endothelium. To compare the clinical material of persons who suffered from or died of COVID-19. To compare the functional disorders of the hearing organs in persons who have experienced akubarotrauma or who have become ill with COVID-19.\nResults and discussion: The clinical material of persons who suffered from COVID-19 or died as a result of it is presented. The functional disorders of the hearing organs in persons who have experienced acubarotrauma or who have become ill with COVID-19 are considered. The reasons for the resistance of thrombotic-fibrous deposits in vessels with systemically damaged endothelium are discussed. Possible methodical approaches to overcoming the considered functional complications are discussed.","PeriodicalId":38742,"journal":{"name":"Otorhinolaryngology Clinics","volume":"43 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Otorhinolaryngology Clinics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37219/2528-8253-2022-6-02","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 1

Abstract

Topicality: Blockage of hemorrhage due to vascular damage is the leading role of the clotting cascade of the hemostasis system. Recently, two types of such damage have become highly relevant. The first of them is caused by viral damage to the endothelium, which leads to uncontrolled cascade activation of the descending system. The second type is caused by aquabarotrauma and associated hydrodynamic shock. Both types of damage lead to the development of thrombotic-fibrous complications of the circulatory system due to the formation of long fibrin deposits. Such deposits are resistant to the action of the fibrinolytic system due to their irregular and chaotic structure. This, in turn, leads to severe functional complications. Aim: Systematize data on molecular and cellular features of systemic damage to the endothelium. To compare the clinical material of persons who suffered from or died of COVID-19. To compare the functional disorders of the hearing organs in persons who have experienced akubarotrauma or who have become ill with COVID-19. Results and discussion: The clinical material of persons who suffered from COVID-19 or died as a result of it is presented. The functional disorders of the hearing organs in persons who have experienced acubarotrauma or who have become ill with COVID-19 are considered. The reasons for the resistance of thrombotic-fibrous deposits in vessels with systemically damaged endothelium are discussed. Possible methodical approaches to overcoming the considered functional complications are discussed.

查看原文本刊更多论文

损伤和感染因子作用下的全身内皮损伤及其功能后果

主题:血管损伤引起的出血阻塞是止血系统的凝血级联反应的主导作用。最近，两种类型的损害变得高度相关。第一种是由病毒破坏内皮细胞引起的，导致下行系统不受控制的级联激活。第二种类型是由水外伤和相关的水动力冲击引起的。由于长纤维蛋白沉积物的形成，这两种类型的损伤都会导致循环系统血栓-纤维并发症的发展。这种沉积物由于其不规则和混乱的结构而抵抗纤溶系统的作用。这反过来又会导致严重的功能并发症。目的:整理内皮细胞全身性损伤的分子和细胞特征。比较新冠肺炎患者和死亡病例的临床资料。比较经历过aku气压创伤或患有COVID-19的人的听力器官功能障碍。结果与讨论:介绍了感染COVID-19或因此死亡的人的临床资料。在经历过针眼外伤或患有COVID-19的人中，听力器官的功能障碍被考虑在内。本文讨论了血管内皮系统受损后血栓纤维沉积抵抗的原因。讨论了克服功能性并发症的可能方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Otorhinolaryngology Clinics Medicine-Otorhinolaryngology

CiteScore

0.10

自引率

0.00%

发文量

期刊介绍： Otorhinolaryngology Clinics: An International Journal is an International periodical devoted at exploring connections between clinical experience and world literature, and understanding of various pathologies and diseases related to the ear, nose and throat. Issues of recent advancements and research related to disease, illness, health and medical science are examined through various evidence-based clinical research studies. This journal proposes to serve as a collection of clinical notes, with an international perspective, along with the recent advances for postgraduates and consultants. The readership for this journal would include a wide variety of healthcare professionals, such as otolaryngologists, head and neck surgeons, ENT nurses as well as scholars and academicians in the field of medicine, trauma, surgery, etc. This journal aims to encourage the analysis of clinical data from various centers all over the world using standardized protocols to develop an international consensual perspective on the management of disorders related to the field of otorhinolaryngology. Recently, we have introduced "Case Reports", "How I Do It" and "Original Research" categories in the process of expanding the scope of the journal. Thisis a peer-reviewed journal of which three issues would be published each year. Each future issue will cover a different topic of special interest in the field of otorhinolaryngology and head and neck surgery. This issue is the first of its kind dedicated to "anesthesia in otorhinolaryngology" and contains a compilation of articles by experienced anesthesiologists dealing with a large volume of ENT and related surgeries. In each issue, the editors give their perspective based on the submitted articles. All non invited articles are peer-reviewed. Peer-revieweing helps in providing unbiased, independent, critical assessment of the results of the research study in question including the scientific process.