Living Skin Substitute Tissue—Is a Replacement for the Autograft Possible?

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-09-05 DOI:10.3390/ebj4030031

Angela L. F. Gibson

引用次数: 0

Abstract

The ideal living tissue skin substitute for use in burn injury does not yet exist. The currently available alternatives to autologous skin grafting require an understanding of their characteristics and limitations to make an informed decision of surgical treatment options. In this review, living tissue substitutes are categorized by autologous and allogeneic cell sources and epidermal-only versus bilayered tissue options. A short summary of the tissue composition, clinical data, and indications is provided. Finally, the gap in technology is defined and future potential areas of research are explored.

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活体皮肤替代组织——自体移植物的替代品可能吗?

目前尚不存在用于烧伤的理想的活体组织皮肤替代品。目前可用的自体皮肤移植替代方案需要了解其特点和局限性，以便做出明智的手术治疗选择。在这篇综述中，活体组织替代品分为自体和异体细胞来源，表皮组织和双层组织。提供了组织组成，临床数据和适应症的简短总结。最后，对技术差距进行了界定，并对未来潜在的研究领域进行了探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.