Antibacterial, antidiarrhoeal and ulcer-protective activity of methanolic extract of Spondias mangifera bark

International journal of health research and innovation Pub Date : 2010-06-09 DOI:10.4314/IJHR.V1I4.55367

M. Arif, K. Zaman, S. Fareed, M. Hussain

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引用次数: 13

Abstract

PURPOSE: To evaluate Spondias mangifera bark for indomethacin-induced ulcer protective and castor-oil induced antidiarrhoeal activity. METHODS: The extracts of S. mangifera were tested for castor-oil induced diarrhea, and intestinal fluid accumulation and propulsion in rats using diphenoxylate hydrochloride and atropine as standard drug. The effect of the extracts on indomethacin-induced ulceration in rats was also evaluated. using cimetidine as positive control. In-vitro antibacterial activity of methanolic and aqueous extract was also evaluated against Escherichia coli, Salmonella typhimurium and Vibrio cholerae bacteria. RESULTS: There was a significant (p < 0.01) inhibition activity against castor oil induced diarrhoea and fluid accumulations in rats when tested at 100 and 200mg/kg. The extracts also showed significant (p < 0.01) reduction in intestinal propulsion in charcoal meal test in rats. The methanol extract inhibited the ulcerogenic effect of indomethacin and good antibacterial activity. CONCLUSION: S. mangifera possesses significant antidiarrhoeal, ulcer protective and antibacterial activities. Keywords: Antidiarrhoeal; Antibacterial; Spondias mangifera bark; Ulcer protective effect.

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芒草树皮甲醇提取物的抗菌、止泻和溃疡保护作用

目的:评价芒果皮对消炎痛致溃疡的保护作用和蓖麻油的抗腹泻作用。方法:以盐酸地苯氧甲酸酯和阿托品为标准药，对枸杞子提取物对蓖麻油致大鼠腹泻和肠道积液推进的影响进行试验。并评价其提取物对消炎痛所致大鼠溃疡的影响。以西咪替丁为阳性对照。研究了甲醇提取物和水提物对大肠杆菌、鼠伤寒沙门菌和霍乱弧菌的体外抑菌活性。结果:蓖麻油浓度为100和200mg/kg时，对大鼠腹泻和积液的抑制作用显著(p < 0.01)。炭粉对大鼠肠道推进力的影响显著(p < 0.01)。甲醇提取物抑制了吲哚美辛的致溃疡作用，具有良好的抗菌活性。结论:芒草具有明显的抗腹泻、保护溃疡和抗菌活性。关键词:Antidiarrhoeal;抗菌;芒果皮;溃疡保护作用。

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International journal of health research and innovation

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